This project aims to standardise the high procyanidin content in wines. Procyanidin is a polyphenol to which a cardioprotective effect is attributed. AINIA has participated in the project by carrying out an in vitro validation of bioaccessibility and cardioprotective effect. In particular, the gastrointestinal digestion process and colonic fermentation have been studied, evaluating the generation of secondary metabolites and the evolution of the intestinal microbiota. To assess the functional effect of wines rich in procyanidins, their impact on cardiovascular disease risk factors has been analysed: blood pressure homeostasis, insulin resistance, HDL cholesterol levels and obesity. This project has been supported by CDTI.