{"id":70959,"date":"2025-11-06T15:09:57","date_gmt":"2025-11-06T15:09:57","guid":{"rendered":"https:\/\/ainia.endesarrollo.pro\/validacao-de-principios-ativos-as-etapas-da-digestao\/"},"modified":"2026-05-26T20:36:53","modified_gmt":"2026-05-26T20:36:53","slug":"validacao-de-principios-ativos-as-etapas-da-digestao","status":"publish","type":"post","link":"https:\/\/ainia.endesarrollo.pro\/pt\/inovacao-tecnologica\/validacao-de-principios-ativos-as-etapas-da-digestao\/","title":{"rendered":"Valida\u00e7\u00e3o cient\u00edfica de princ\u00edpios ativos: as etapas da digest\u00e3o"},"content":{"rendered":"\n<span data-contrast=\"none\"><span class=\"TextRun SCXW41880406 BCX8\" lang=\"ES-ES\" xml_lang=\"ES-ES\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW41880406 BCX8\"><span class=\"TextRun SCXW194446391 BCX8\" lang=\"ES-ES\" xml_lang=\"ES-ES\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW194446391 BCX8\"><span class=\"TextRun SCXW1005685 BCX8\" lang=\"ES-ES\" xml_lang=\"ES-ES\" data-contrast=\"auto\"><span class=\"NormalTextRun SpellingErrorV2Themed SCXW1005685 BCX8\"><\/span><\/span><\/span><\/span><\/span><\/span><\/span><span data-contrast=\"auto\">Compreender, avaliar e demonstrar o mecanismo de a\u00e7\u00e3o dos ingredientes funcionais \u00e9 essencial para as empresas do setor. A sociedade recorre cada vez mais a estes compostos para complementar a alimenta\u00e7\u00e3o, mas n\u00e3o basta inclu\u00ed-los numa formula\u00e7\u00e3o. \u00c9 imprescind\u00edvel justificar a sua utiliza\u00e7\u00e3o com crit\u00e9rios cient\u00edficos rigorosos: devem ser cuidadosamente selecionados e sustentados por investiga\u00e7\u00e3o, desenvolvimento e valida\u00e7\u00e3o s\u00f3lida do efeito funcional que lhes \u00e9 atribu\u00eddo.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span>\n<h2 aria-level=\"3\"><b><span data-contrast=\"none\">Como um ingrediente se comporta no sistema digestivo?<\/span><\/b><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;134245418&quot;:true,&quot;134245529&quot;:true,&quot;335559738&quot;:281,&quot;335559739&quot;:281}\">\u00a0<\/span><\/h2>\n<span data-contrast=\"auto\">Quando ingerimos um alimento ou suplemento, os seus <\/span><b><span data-contrast=\"auto\">princ\u00edpios ativos<\/span><\/b><span data-contrast=\"auto\"> percorrem um trajeto complexo ao longo do sistema digestivo. Durante este percurso, podem sofrer transforma\u00e7\u00f5es qu\u00edmicas, interagir com enzimas digestivas, ser afetados pelo pH ou entrar em contacto com o microbiota intestinal.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span>\n\n<span data-contrast=\"auto\">\u00c9, portanto, essencial saber:<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span>\n<ul>\n \t<li><span data-contrast=\"auto\">Se o ingrediente resiste \u00e0s condi\u00e7\u00f5es digestivas ou se se degrada antes de exercer o seu efeito.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/li>\n \t<li><span data-contrast=\"auto\">Em que forma chega ao intestino e se \u00e9 biodispon\u00edvel, ou seja, absorv\u00edvel.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/li>\n \t<li><span data-contrast=\"auto\">Que<strong><a href=\"https:\/\/www.ainia.com\/pt\/ainia-news\/qual-e-o-papel-da-microbiota-do-intestino-no-desenvolvimento-da-obesidade\/\"> impacto tem no microbiota intestinal<\/a> <\/strong>e se gera metabolitos bioativos.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/li>\n<\/ul>\n<span data-contrast=\"auto\">Este conhecimento permite conceber produtos mais eficazes e justificar de forma objetiva os benef\u00edcios que lhes s\u00e3o atribu\u00eddos.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span>\n<h2 aria-level=\"2\"><b><span data-contrast=\"none\">As etapas da digest\u00e3o<\/span><\/b><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;134245418&quot;:true,&quot;134245529&quot;:true,&quot;335559738&quot;:299,&quot;335559739&quot;:299}\">\u00a0<\/span><\/h2>\n<span data-contrast=\"auto\">O sistema digestivo humano divide-se em v\u00e1rias <\/span><b><span data-contrast=\"auto\">etapas da digest\u00e3o<\/span><\/b><span data-contrast=\"auto\">, cada uma com condi\u00e7\u00f5es muito diferentes que podem influenciar o comportamento de um <\/span><b><span data-contrast=\"auto\">princ\u00edpio ativo<\/span><\/b><span data-contrast=\"auto\">.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span>\n<h3 aria-level=\"3\"><b><span data-contrast=\"none\"><img fetchpriority=\"high\" decoding=\"async\" class=\"alignnone size-large wp-image-184112\" src=\"https:\/\/ainia.endesarrollo.pro\/wp-content\/uploads\/processo-digestivo-1024x680-1.png\" alt=\"o processo digestivo\" width=\"1024\" height=\"680\" \/><\/span><\/b><strong>Fase oral<\/strong><\/h3>\n<span data-contrast=\"auto\">A digest\u00e3o come\u00e7a na boca, na chamada fase oral. Aqui, os dentes trituram os alimentos em part\u00edculas mais pequenas, facilitando o seu processamento posterior. Ao mesmo tempo, as <strong><a href=\"https:\/\/www.ainia.com\/pt\/ainia-news\/funcao-das-glandulas-salivares-no-sistema-digestivo-a-importancia-da-cavidade-bucal\/\">gl\u00e2ndulas salivares<\/a><\/strong> desempenham um papel fundamental ao secretar enzimas como a amilase salivar, que inicia a decomposi\u00e7\u00e3o dos hidratos de carbono complexos.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span>\n\n<span data-contrast=\"auto\">Depois de bem mastigado e misturado com a saliva, o alimento transforma-se no bolo alimentar, que desce pelo es\u00f3fago at\u00e9 ao est\u00f4mago, dando in\u00edcio \u00e0 fase g\u00e1strica.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span>\n<h3 aria-level=\"3\"><strong>Fase g\u00e1strica\u00a0<\/strong><\/h3>\n<span data-contrast=\"auto\">Quando o bolo alimentar chega ao est\u00f4mago, come\u00e7a a fase g\u00e1strica, caracterizada por um ambiente altamente \u00e1cido. Aqui, os alimentos misturam-se com os sucos g\u00e1stricos, uma combina\u00e7\u00e3o de \u00e1cido clor\u00eddrico e enzimas digestivas, destacando-se a pepsina, respons\u00e1vel por decompor as prote\u00ednas em fragmentos mais pequenos.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span>\n\n<span data-contrast=\"auto\">Esta etapa cumpre fun\u00e7\u00f5es essenciais:<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span>\n<ul>\n \t<li><span data-contrast=\"auto\">Desnatura prote\u00ednas, facilitando a sua digest\u00e3o.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/li>\n \t<li><span data-contrast=\"auto\">Ativa enzimas espec\u00edficas.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/li>\n \t<li><span data-contrast=\"auto\">Elimina microrganismos patog\u00e9nicos gra\u00e7as ao baixo pH.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/li>\n<\/ul>\n<span data-contrast=\"auto\">A dura\u00e7\u00e3o desta fase varia entre 2 e 4 horas, dependendo do tipo de alimento ingerido (por exemplo, as prote\u00ednas necessitam de mais tempo do que os hidratos de carbono simples). <\/span><span data-contrast=\"auto\">O resultado \u00e9 uma mistura semil\u00edquida chamada quimo, que \u00e9 libertada gradualmente para o intestino delgado, onde continuam as <\/span><b><span data-contrast=\"auto\">etapas da digest\u00e3o<\/span><\/b><span data-contrast=\"auto\">.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span>\n<h3 aria-level=\"3\"><strong>Fase intestinal: absor\u00e7\u00e3o e biodisponibilidade\u00a0<\/strong><\/h3>\n<span data-contrast=\"auto\">Na fase intestinal, o quimo passa para o intestino delgado, onde ocorre a maior parte da digest\u00e3o e da absor\u00e7\u00e3o de nutrientes. \u00c9 tamb\u00e9m a etapa mais relevante para estudar a absor\u00e7\u00e3o de nutrientes e determinar os poss\u00edveis efeitos de um <\/span><b><span data-contrast=\"auto\">princ\u00edpio ativo<\/span><\/b><span data-contrast=\"auto\"> ou ingrediente funcional.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span>\n\n<span data-contrast=\"auto\">Esta fase das <\/span><b><span data-contrast=\"auto\">etapas da digest\u00e3o<\/span><\/b><span data-contrast=\"auto\"> \u00e9 sustentada pela a\u00e7\u00e3o combinada das enzimas pancre\u00e1ticas e dos sais biliares, que decomp\u00f5em gorduras, prote\u00ednas e hidratos de carbono em mol\u00e9culas mais simples, prontas para serem absorvidas pelo organismo.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span>\n\n<span data-contrast=\"auto\">Durante esta etapa:<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span>\n<ul>\n \t<li><span data-contrast=\"auto\">Ocorre a digest\u00e3o enzim\u00e1tica mais intensa.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/li>\n \t<li><span data-contrast=\"auto\">S\u00e3o absorvidas vitaminas, minerais, amino\u00e1cidos, \u00e1cidos gordos e a\u00e7\u00facares simples.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/li>\n \t<li><span data-contrast=\"auto\">O intestino regula a biodisponibilidade dos princ\u00edpios ativos ou ingredientes funcionais.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/li>\n<\/ul>\n<span data-contrast=\"auto\">Esta fase pode durar entre 4 e 6 horas, dependendo do tipo de alimento e do estado fisiol\u00f3gico da pessoa.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span>\n<h3 aria-level=\"3\"><strong>Fase c\u00f3lica: intera\u00e7\u00e3o com o microbiota e elimina\u00e7\u00e3o final\u00a0<\/strong><\/h3>\n<span data-contrast=\"auto\">Ap\u00f3s a absor\u00e7\u00e3o da maioria dos nutrientes no intestino delgado, o material n\u00e3o digerido passa para o intestino grosso, onde se inicia a fase c\u00f3lica. Do ponto de vista cient\u00edfico, esta fase \u00e9 essencial para avaliar se um ingrediente funcional tem efeito prebi\u00f3tico, se modula o microbiota ou se gera metabolitos ben\u00e9ficos.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span>\n\n<span data-contrast=\"auto\">Estes efeitos podem ser estudados de forma controlada atrav\u00e9s de <\/span><strong><a href=\"https:\/\/www.ainia.com\/pt\/ensaios-em-digestor-dinamico-in-vitro-bioacessibilidade-e-ensaios-em-cultivo-celular-biodisponibilidade\/\">modelos de simula\u00e7\u00e3o gastrointestinal<\/a><\/strong><span data-contrast=\"auto\">, que permitem reproduzir de maneira precisa e completa as <\/span><b><span data-contrast=\"auto\">etapas da digest\u00e3o<\/span><\/b><span data-contrast=\"auto\">, fornecendo informa\u00e7\u00f5es detalhadas sobre o impacto dos ingredientes no microbiota e no seu metabolismo.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span>\n\n<span data-contrast=\"auto\">Esta etapa inclui dois processos fundamentais: fermenta\u00e7\u00e3o microbiana e elimina\u00e7\u00e3o.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span>\n\n<span data-contrast=\"auto\">No c\u00f3lon:<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span>\n<ul>\n \t<li><span data-contrast=\"auto\">Absorve-se \u00e1gua e alguns minerais residuais, ajudando a compactar o conte\u00fado intestinal.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/li>\n \t<li><span data-contrast=\"auto\">O microbiota intestinal atua sobre os compostos n\u00e3o digeridos, gerando metabolitos como os \u00e1cidos gordos de cadeia curta (AGCC), que desempenham um papel importante na sa\u00fade metab\u00f3lica, imunol\u00f3gica e intestinal.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/li>\n \t<li><span data-contrast=\"auto\">Compreender profundamente esta fase permite desenvolver solu\u00e7\u00f5es para problemas mais complexos, como inflama\u00e7\u00e3o intestinal cr\u00f3nica ou cancro colorretal.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/li>\n \t<li><span data-contrast=\"auto\">O conte\u00fado pode permanecer entre 12 e 24 horas antes de ser eliminado pelo reto sob a forma de fezes.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/li>\n<\/ul>\n<h2><strong><img decoding=\"async\" class=\"alignnone size-large wp-image-181261\" src=\"https:\/\/ainia.endesarrollo.pro\/wp-content\/uploads\/digestor-dinamico-tres-1024x682-1.jpg\" alt=\"digestor dinamico\" width=\"1024\" height=\"682\" \/><\/strong><\/h2>\n<h2 aria-level=\"2\"><b><span data-contrast=\"none\">Modelos de simula\u00e7\u00e3o das etapas da digest\u00e3o para validar princ\u00edpios ativos<\/span><\/b><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;134245418&quot;:true,&quot;134245529&quot;:true,&quot;335559738&quot;:299,&quot;335559739&quot;:299}\">\u00a0<\/span><\/h2>\n<span data-contrast=\"auto\">Para obter evid\u00eancias cient\u00edficas sobre o efeito real de um <\/span><b><span data-contrast=\"auto\">princ\u00edpio ativo<\/span><\/b><span data-contrast=\"auto\"> no organismo, os <a href=\"https:\/\/www.ainia.com\/pt\/ensaios-em-digestor-dinamico-in-vitro-bioacessibilidade-e-ensaios-em-cultivo-celular-biodisponibilidade\/\"><strong>modelos de digest\u00e3o<\/strong> <\/a><\/span>in vitro<span data-contrast=\"auto\"> tornaram-se uma ferramenta essencial. Estes ensaios permitem simular de forma controlada as condi\u00e7\u00f5es fisiol\u00f3gicas que ocorrem ao longo de todas as <\/span><b><span data-contrast=\"auto\">etapas da digest\u00e3o<\/span><\/b><span data-contrast=\"auto\"> \u0097 desde a fase oral at\u00e9 \u00e0 fermenta\u00e7\u00e3o c\u00f3lica.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span>\n\n<span data-contrast=\"auto\">Os modelos din\u00e2micos <\/span><i><span data-contrast=\"auto\">in vitro<\/span><\/i><span data-contrast=\"auto\"> reproduzem com precis\u00e3o vari\u00e1veis-chave como o pH, o tempo de tr\u00e2nsito, a presen\u00e7a de enzimas digestivas e a concentra\u00e7\u00e3o de sais em cada etapa do sistema digestivo.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span>\n\n<span data-contrast=\"auto\">Al\u00e9m de permitir estudar o comportamento de um ingrediente ao longo do trato gastrointestinal, oferecem uma forma eficaz de analisar o seu potencial efeito funcional ou ben\u00e9fico ap\u00f3s a digest\u00e3o e absor\u00e7\u00e3o. Esta metodologia \u00e9 tamb\u00e9m aplicada com sucesso na \u00e1rea da sa\u00fade digestiva animal, onde os digestores <\/span><i><span data-contrast=\"auto\">in vitro<\/span><\/i><span data-contrast=\"auto\"> permitem avaliar ingredientes funcionais sem necessidade de ensaios em animais.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span>\n\n<span data-contrast=\"auto\">Estes ensaios normalmente abrangem:<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span>\n<ul>\n \t<li><b><span data-contrast=\"auto\">Fase oral<\/span><\/b><span data-contrast=\"auto\">, onde se avalia a liberta\u00e7\u00e3o inicial do ingrediente.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/li>\n \t<li><b><span data-contrast=\"auto\">Fase g\u00e1strica<\/span><\/b><span data-contrast=\"auto\">, para estudar a sua estabilidade em condi\u00e7\u00f5es \u00e1cidas.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/li>\n \t<li><b><span data-contrast=\"auto\">Fase intestinal<\/span><\/b><span data-contrast=\"auto\">, essencial para determinar a biodisponibilidade.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/li>\n \t<li><b><span data-contrast=\"auto\">Fase c\u00f3lica<\/span><\/b><span data-contrast=\"auto\">, que permite analisar a fermenta\u00e7\u00e3o microbiana e a produ\u00e7\u00e3o de metabolitos ativos.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/li>\n<\/ul>\n<span data-contrast=\"auto\">Ap\u00f3s a digest\u00e3o, \u00e9 poss\u00edvel simular tamb\u00e9m a absor\u00e7\u00e3o intestinal utilizando <strong>modelos celulares como a linha Caco-2,<\/strong> representativa do epit\u00e9lio intestinal humano. Esta t\u00e9cnica permite estimar que parte do composto ingerido pode realmente chegar \u00e0 corrente sangu\u00ednea (fra\u00e7\u00e3o biodispon\u00edvel), o que \u00e9 fundamental no caso de ingredientes com efeito sist\u00e9mico.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span>\n\n<span data-contrast=\"auto\">Gra\u00e7as \u00e0 sua versatilidade, reprodutibilidade e menor custo em compara\u00e7\u00e3o com os ensaios <\/span><i><span data-contrast=\"auto\">in vivo<\/span><\/i><span data-contrast=\"auto\">, estes modelos s\u00e3o cada vez mais utilizados tanto na investiga\u00e7\u00e3o como no desenvolvimento de novos produtos nutrac\u00eauticos, funcionais e veterin\u00e1rios.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:1,&quot;335551620&quot;:1,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0\u00a0<\/span>\n","protected":false},"excerpt":{"rendered":"<p>Compreender, avaliar e demonstrar o mecanismo de a\u00e7\u00e3o dos ingredientes funcionais \u00e9 essencial para as empresas do setor. A sociedade recorre cada vez mais a estes compostos para complementar a alimenta\u00e7\u00e3o, mas n\u00e3o basta inclu\u00ed-los numa formula\u00e7\u00e3o. \u00c9 imprescind\u00edvel justificar a sua utiliza\u00e7\u00e3o com crit\u00e9rios cient\u00edficos rigorosos: devem ser cuidadosamente selecionados e sustentados por investiga\u00e7\u00e3o, [&hellip;]<\/p>\n","protected":false},"author":390,"featured_media":50652,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[85],"tags":[],"tipo-documento":[],"class_list":["post-70959","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-inovacao-tecnologica"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Valida\u00e7\u00e3o cient\u00edfica de princ\u00edpios ativos: as etapas da digest\u00e3o<\/title>\n<meta name=\"description\" content=\"Etapas da digest\u00e3o: oral, g\u00e1strica, intestinal e c\u00f3lica. 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Mi especialidad se centra en el desarrollo de modelos avanzados que simulan el tracto gastrointestinal y la fermentaci\u00f3n col\u00f3nica, as\u00ed como \u00f3rganos diana mediante t\u00e9cnicas como cultivo celular, bioimpresi\u00f3n 3D y \u00f3rganos-on-chip. Doctora en Bioqu\u00edmica y Biolog\u00eda Molecular por la Universitat de Val\u00e8ncia, combino una s\u00f3lida formaci\u00f3n cient\u00edfica con experiencia en gesti\u00f3n y transferencia tecnol\u00f3gica. Colaboro con empresas de los sectores alimentario, cosm\u00e9tico y nutrac\u00e9utico para impulsar soluciones innovadoras basadas en evidencia cient\u00edfica. He participado en proyectos nacionales e internacionales como PHARMANOVA, MEAT4FUTURE y PATHWAY-27, y soy miembro activo de redes como INFOGEST, INFOGUT y Food4Life. Adem\u00e1s, imparto formaci\u00f3n especializada en congresos y jornadas sectoriales, contribuyendo a la divulgaci\u00f3n cient\u00edfica y al avance de la investigaci\u00f3n aplicada.","sameAs":["https:\/\/www.ainia.com\/contactar-lidia-tomas\/","'=https:\/\/www.linkedin.com\/public-profile\/settings?lipi=urnlipaged_flagship3_profile_self_edit_contact-infoSUVPYk6QOSvsEj2ZXWSXQ"],"url":"https:\/\/ainia.endesarrollo.pro\/pt\/author\/lidia-tomas-cobos\/"}]}},"_links":{"self":[{"href":"https:\/\/ainia.endesarrollo.pro\/pt\/wp-json\/wp\/v2\/posts\/70959","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ainia.endesarrollo.pro\/pt\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ainia.endesarrollo.pro\/pt\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ainia.endesarrollo.pro\/pt\/wp-json\/wp\/v2\/users\/390"}],"replies":[{"embeddable":true,"href":"https:\/\/ainia.endesarrollo.pro\/pt\/wp-json\/wp\/v2\/comments?post=70959"}],"version-history":[{"count":1,"href":"https:\/\/ainia.endesarrollo.pro\/pt\/wp-json\/wp\/v2\/posts\/70959\/revisions"}],"predecessor-version":[{"id":70961,"href":"https:\/\/ainia.endesarrollo.pro\/pt\/wp-json\/wp\/v2\/posts\/70959\/revisions\/70961"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ainia.endesarrollo.pro\/pt\/wp-json\/wp\/v2\/media\/50652"}],"wp:attachment":[{"href":"https:\/\/ainia.endesarrollo.pro\/pt\/wp-json\/wp\/v2\/media?parent=70959"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ainia.endesarrollo.pro\/pt\/wp-json\/wp\/v2\/categories?post=70959"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ainia.endesarrollo.pro\/pt\/wp-json\/wp\/v2\/tags?post=70959"},{"taxonomy":"tipo-documento","embeddable":true,"href":"https:\/\/ainia.endesarrollo.pro\/pt\/wp-json\/wp\/v2\/tipo-documento?post=70959"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}