{"id":70870,"date":"2025-07-18T06:52:14","date_gmt":"2025-07-18T06:52:14","guid":{"rendered":"https:\/\/ainia.endesarrollo.pro\/qual-e-o-papel-da-microbiota-do-intestino-no-desenvolvimento-da-obesidade\/"},"modified":"2026-05-26T20:36:05","modified_gmt":"2026-05-26T20:36:05","slug":"qual-e-o-papel-da-microbiota-do-intestino-no-desenvolvimento-da-obesidade","status":"publish","type":"post","link":"https:\/\/ainia.endesarrollo.pro\/pt\/inovacao-tecnologica\/qual-e-o-papel-da-microbiota-do-intestino-no-desenvolvimento-da-obesidade\/","title":{"rendered":"Qual \u00e9 o papel da microbiota do intestino no desenvolvimento da obesidade?"},"content":{"rendered":"\n<span data-contrast=\"auto\">O aumento vertiginoso da obesidade nas \u00faltimas d\u00e9cadas levou \u00e0 procura de novas explica\u00e7\u00f5es para al\u00e9m da alimenta\u00e7\u00e3o e da inatividade f\u00edsica. Entre os fatores emergentes mais relevantes encontra-se a microbiota do intestino, uma comunidade de microrganismos que habita o trato digestivo e que participa ativamente em processos metab\u00f3licos, imunol\u00f3gicos e digestivos. A sua composi\u00e7\u00e3o, diversidade e funcionalidade est\u00e3o diretamente relacionadas com o risco de desenvolver obesidade e dist\u00farbios metab\u00f3licos associados.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:0,&quot;335551620&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span>\n<h2 aria-level=\"2\"><b><span data-contrast=\"none\">Microbiota do intestino: um fator-chave na digest\u00e3o, perda de peso e sistema imunit\u00e1rio<\/span><\/b><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;134245418&quot;:true,&quot;134245529&quot;:true,&quot;335551550&quot;:0,&quot;335551620&quot;:0,&quot;335559738&quot;:299,&quot;335559739&quot;:299}\">\u00a0<\/span><\/h2>\n<span data-contrast=\"auto\">A <strong>microbiota do intestino<\/strong> n\u00e3o s\u00f3 interv\u00e9m na digest\u00e3o e absor\u00e7\u00e3o de nutrientes, como tamb\u00e9m desempenha fun\u00e7\u00f5es metab\u00f3licas essenciais, tais como:<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:0,&quot;335551620&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span>\n<ul>\n \t<li aria-setsize=\"-1\" data-leveltext=\"?\" data-font=\"Symbol\" data-listid=\"12\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559683&quot;:0,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;?&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">A <strong>s\u00edntese de vitaminas<\/strong> (por exemplo, do grupo B e da vitamina K)<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:0,&quot;335551620&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n \t<li aria-setsize=\"-1\" data-leveltext=\"?\" data-font=\"Symbol\" data-listid=\"12\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559683&quot;:0,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;?&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"auto\">A <strong>obten\u00e7\u00e3o de energia a partir de compostos<\/strong> n\u00e3o diger\u00edveis, como a fibra alimentar<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:0,&quot;335551620&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n \t<li aria-setsize=\"-1\" data-leveltext=\"?\" data-font=\"Symbol\" data-listid=\"12\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559683&quot;:0,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;?&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" data-aria-posinset=\"3\" data-aria-level=\"1\"><span data-contrast=\"auto\">A <strong>modula\u00e7\u00e3o do sistema imunit\u00e1rio<\/strong><\/span><strong>\u00a0<\/strong><\/li>\n<\/ul>\n<span data-contrast=\"auto\">Al\u00e9m disso, contribui para a prote\u00e7\u00e3o contra microrganismos patog\u00e9nicos por mecanismos de competi\u00e7\u00e3o e produ\u00e7\u00e3o de compostos antimicrobianos, colaborando na manuten\u00e7\u00e3o da <strong>integridade da barreira intestinal.<\/strong><\/span><strong>\u00a0<\/strong>\n\n<span data-contrast=\"auto\">Em pessoas com <strong>obesidade<\/strong>, foi descrita uma <strong>menor diversidade microbiana e altera\u00e7\u00f5es na propor\u00e7\u00e3o relativa dos principais filos bacterianos<\/strong>, especialmente um aumento da raz\u00e3o <strong>Firmicutes\/Bacteroidetes<\/strong>. Estas modifica\u00e7\u00f5es podem melhorar a efici\u00eancia na extra\u00e7\u00e3o de energia da dieta e favorecer um estado de <strong>inflama\u00e7\u00e3o cr\u00f3nica<\/strong> de baixo grau, ambos fatores implicados no <strong>ganho de peso e em altera\u00e7\u00f5es metab\u00f3licas associadas.<\/strong><\/span><strong>\u00a0<\/strong>\n\n<span data-contrast=\"auto\">Por outro lado, alguns<strong> metabolitos produzidos pela microbiota<\/strong>, como os <strong>\u00e1cidos gordos de cadeia curta (AGCC): <\/strong>acetato, propionato e butirata;\u00a0 atuam como verdadeiros moduladores metab\u00f3licos. Estes compostos influenciam o<strong> metabolismo lip\u00eddico e de hidratos de carbono<\/strong>, a regula\u00e7\u00e3o do apetite atrav\u00e9s de sinais hormonais (como GLP-1 e PYY), a <strong>motilidade intestinal e a resposta imunit\u00e1ria<\/strong>, refor\u00e7ando o papel essencial da microbiota na homeostase do organismo.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:0,&quot;335551620&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span>\n<h2 aria-level=\"2\"><b><span data-contrast=\"none\">Modula\u00e7\u00e3o da microbiota do intestino atrav\u00e9s de ingredientes funcionais<\/span><\/b><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;134245418&quot;:true,&quot;134245529&quot;:true,&quot;335551550&quot;:0,&quot;335551620&quot;:0,&quot;335559738&quot;:299,&quot;335559739&quot;:299}\">\u00a0<\/span><\/h2>\n<span data-contrast=\"auto\"><img fetchpriority=\"high\" decoding=\"async\" class=\"alignnone size-large wp-image-181234\" src=\"https:\/\/ainia.endesarrollo.pro\/wp-content\/uploads\/Microbiota-PT-1024x680-1.png\" alt=\"Infografia que mostra tr\u00eas estrat\u00e9gias para modular a microbiota do intestino: probi\u00f3ticos, prebi\u00f3ticos e simbi\u00f3ticos\" width=\"1024\" height=\"680\" \/><\/span>\n\n<span data-contrast=\"auto\">A <strong>microbiota do intestin<\/strong>o \u00e9 altamente sens\u00edvel aos componentes da alimenta\u00e7\u00e3o. Por isso, uma das abordagens mais promissoras na<strong> preven\u00e7\u00e3o e tratamento da obesidade<\/strong> consiste na sua <strong>modula\u00e7\u00e3o seletiva<\/strong> atrav\u00e9s de ingredientes funcionais como probi\u00f3ticos, prebi\u00f3ticos ou fibras ferment\u00e1veis.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:0,&quot;335551620&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span>\n<h3 aria-level=\"3\"><strong>Probi\u00f3ticos: microrganismos que refor\u00e7am o equil\u00edbrio intestinal\u00a0<\/strong><\/h3>\n<span data-contrast=\"auto\">Os <strong>probi\u00f3ticos<\/strong> s\u00e3o microrganismos vivos que, administrados em quantidades adequadas, exercem <strong>efeitos ben\u00e9ficos na sa\u00fade do hospedeiro<\/strong>. Diversas estirpes probi\u00f3ticas demonstraram capacidade para<strong> modificar a composi\u00e7\u00e3o e atividade da microbiota<\/strong>, resistir \u00e0 passagem pelo trato gastrointestinal e atuar diretamente sobre o <strong>epit\u00e9lio intestinal e o sistema imunit\u00e1rio.<\/strong> Exemplos como Lactobacillus casei DN 114-001 e CRL 431 mostraram benef\u00edcios tanto na modula\u00e7\u00e3o microbiana como no <strong>refor\u00e7o da imunidade intestinal e sist\u00e9mica.<\/strong><\/span><strong>\u00a0<\/strong>\n<h3 aria-level=\"3\"><strong>Prebi\u00f3ticos: nutrientes funcionais para as bact\u00e9rias ben\u00e9ficas\u00a0<\/strong><\/h3>\n<span data-contrast=\"auto\">Os <strong>prebi\u00f3ticos<\/strong> s\u00e3o ingredientes n\u00e3o diger\u00edveis, como certos oligossacar\u00eddeos,\u00a0 que estimulam seletivamente o crescimento de bact\u00e9rias ben\u00e9ficas no c\u00f3lon, como bifidobact\u00e9rias e lactobacilos. O seu efeito traduz-se numa melhor absor\u00e7\u00e3o de minerais e vitaminas, <strong>refor\u00e7o da barreira intestinal e redu\u00e7\u00e3o do risco de doen\u00e7as digestivas e inflamat\u00f3rias<\/strong>. Compostos como a inulina e os<strong> fructooligossacar\u00eddeos (FOS)<\/strong> est\u00e3o entre os mais estudados pelo seu efeito prebi\u00f3tico.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:0,&quot;335551620&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span>\n<h3 aria-level=\"3\"><strong>Simbi\u00f3ticos e alimentos fermentados: sinergia para a sa\u00fade intestinal\u00a0<\/strong><\/h3>\n<span data-contrast=\"auto\">A combina\u00e7\u00e3o de probi\u00f3ticos e prebi\u00f3ticos, conhecida como <strong>simbi\u00f3ticos<\/strong>, juntamente com outros ingredientes bioativos derivados de alimentos fermentados, impulsiona o desenvolvimento de <strong>alimentos funcionais<\/strong> orientados para melhorar o equil\u00edbrio do ecossistema intestinal e <strong>apoiar a sa\u00fade metab\u00f3lica.<\/strong><\/span><strong>\u00a0<\/strong>\n\n<span data-contrast=\"auto\">Estes produtos integram-se facilmente na alimenta\u00e7\u00e3o di\u00e1ria e podem gerar<strong> efeitos fisiol\u00f3gicos mensur\u00e1veis<\/strong>, com aplica\u00e7\u00f5es diretas em condi\u00e7\u00f5es como obesidade, i<strong>nflama\u00e7\u00e3o cr\u00f3nica ou s\u00edndrome metab\u00f3lica.<\/strong><\/span><strong>\u00a0<\/strong>\n<h3 aria-level=\"3\"><strong>Tecnologias para estudar a efic\u00e1cia de ingredientes funcionais\u00a0<\/strong><\/h3>\n<span data-contrast=\"auto\">Para que estes produtos sejam realmente eficazes, \u00e9 fundamental compreender como interagem com o sistema digestivo e com a microbiota do intestino. Neste contexto, os modelos de simula\u00e7\u00e3o digestiva in vitro s\u00e3o ferramentas-chave. Estes sistemas reproduzem com precis\u00e3o as condi\u00e7\u00f5es do aparelho digestivo humano, incluindo a fase de<\/span><a href=\"https:\/\/www.ainia.com\/pt\/ensaios-em-digestor-dinamico-de-fermentacao-colonica-modulacao-da-microbiota\/\"><b><span data-contrast=\"none\"> fermenta\u00e7\u00e3o col\u00f3nica<\/span><\/b><\/a><span data-contrast=\"auto\">, permitindo:<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:0,&quot;335551620&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span>\n<ul>\n \t<li aria-setsize=\"-1\" data-leveltext=\"?\" data-font=\"Symbol\" data-listid=\"13\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559683&quot;:0,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;?&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">Avaliar a <strong>bioacessibilidade<\/strong> de ingredientes funcionais<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:0,&quot;335551620&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n \t<li aria-setsize=\"-1\" data-leveltext=\"?\" data-font=\"Symbol\" data-listid=\"13\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559683&quot;:0,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;?&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"auto\">Estudar a <strong>modula\u00e7\u00e3o microbiana<\/strong> induzida por diferentes compostos<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:0,&quot;335551620&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n \t<li aria-setsize=\"-1\" data-leveltext=\"?\" data-font=\"Symbol\" data-listid=\"13\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559683&quot;:0,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;?&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" data-aria-posinset=\"3\" data-aria-level=\"1\"><span data-contrast=\"auto\">Analisar a <strong>produ\u00e7\u00e3o de metabolitos-chave<\/strong>, como os \u00e1cidos gordos de cadeia curta (AGCC)<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:0,&quot;335551620&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n \t<li aria-setsize=\"-1\" data-leveltext=\"?\" data-font=\"Symbol\" data-listid=\"13\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559683&quot;:0,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;?&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" data-aria-posinset=\"4\" data-aria-level=\"1\"><span data-contrast=\"auto\">Prever a <strong>efic\u00e1cia potencial de alimentos e suplementos funcionais<\/strong><\/span><strong>\u00a0<\/strong><\/li>\n<\/ul>\n<span data-contrast=\"auto\">Integrar este tipo de ferramentas nas <strong>fases de I&amp;D<\/strong> de novos alimentos, suplementos ou nutrac\u00eauticos n\u00e3o s\u00f3 aporta rigor cient\u00edfico, como tamb\u00e9m facilita o desenvolvimento de <strong>produtos mais eficazes, seguros e orientados \u00e0s reais necessidades do consumidor<\/strong>. No AINIA, desenvolvemos e aplicamos <\/span><a href=\"https:\/\/www.ainia.com\/pt\/ensaios-em-digestor-dinamico-in-vitro-bioacessibilidade-e-ensaios-em-cultivo-celular-biodisponibilidade\/\"><b><span data-contrast=\"none\">tecnologias avan\u00e7adas in vitro<\/span><\/b><\/a><span data-contrast=\"auto\"> para avaliar cientificamente o impacto de ingredientes e produtos na sa\u00fade digestiva e metab\u00f3lica, acelerando a sua valida\u00e7\u00e3o e entrada no mercado.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:0,&quot;335551620&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span>\n<h2 aria-level=\"2\"><b><span data-contrast=\"none\">Avalia\u00e7\u00e3o do efeito sobre a microbiota do intestino atrav\u00e9s de modelos digestivos in vitro<\/span><\/b><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;134245418&quot;:true,&quot;134245529&quot;:true,&quot;335551550&quot;:0,&quot;335551620&quot;:0,&quot;335559738&quot;:299,&quot;335559739&quot;:299}\">\u00a0<\/span><\/h2>\n<span data-contrast=\"auto\">Para comprovar se um ingrediente funcional tem realmente a capacidade de <a href=\"https:\/\/www.ainia.com\/pt\/ensaios-em-digestor-dinamico-de-fermentacao-colonica-modulacao-da-microbiota\/\"><strong>modular favoravelmente a microbiota do intestino<\/strong><\/a>, \u00e9 fundamental dispor de<\/span><b><span data-contrast=\"none\"> modelos de simula\u00e7\u00e3o digestiva in vitro<\/span><\/b><span data-contrast=\"auto\"> que reproduzam com precis\u00e3o as condi\u00e7\u00f5es fisiol\u00f3gicas do trato gastrointestinal humano.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:0,&quot;335551620&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span>\n\n<span data-contrast=\"auto\">Estes sistemas permitem estudar a <strong>intera\u00e7\u00e3o entre o ingrediente e a microbiota col\u00f3nica<\/strong> num ambiente controlado, reproduzindo aspetos-chave do processo digestivo.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:0,&quot;335551620&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span>\n<h3 aria-level=\"3\"><b><span data-contrast=\"none\"><img decoding=\"async\" class=\"alignnone size-large wp-image-181175\" src=\"https:\/\/ainia.endesarrollo.pro\/wp-content\/uploads\/digestores-dinamicos-dos-1024x682-1.jpg\" alt=\"In vitro dynamic gastrointestinal simulators used for studying intestinal microbiota and evaluating functional ingredients related to gut microbiota weight loss\" width=\"1024\" height=\"682\" \/><\/span><\/b><\/h3>\n<h3 aria-level=\"3\"><strong>O que oferecem os modelos digestivos in vitro?\u00a0<\/strong><\/h3>\n<ul>\n \t<li aria-setsize=\"-1\" data-leveltext=\"?\" data-font=\"Symbol\" data-listid=\"14\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559683&quot;:0,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;?&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\"><strong>Simulam fielmente<\/strong> as condi\u00e7\u00f5es reais de pH, tempo de tr\u00e2nsito, atividade enzim\u00e1tica e sais em cada fase digestiva (oral, g\u00e1strica, intestinal e col\u00f3nica)<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:0,&quot;335551620&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n \t<li aria-setsize=\"-1\" data-leveltext=\"?\" data-font=\"Symbol\" data-listid=\"14\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559683&quot;:0,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;?&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"auto\"><strong>Avaliam a fermenta\u00e7\u00e3o col\u00f3nica<\/strong> e as altera\u00e7\u00f5es na composi\u00e7\u00e3o e atividade microbiana frente a um ingrediente ou matriz alimentar<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:0,&quot;335551620&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n \t<li aria-setsize=\"-1\" data-leveltext=\"?\" data-font=\"Symbol\" data-listid=\"14\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559683&quot;:0,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;?&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" data-aria-posinset=\"3\" data-aria-level=\"1\"><span data-contrast=\"auto\"><strong>Permitem quantificar metabolitos bioativos<\/strong>, como os \u00e1cidos gordos de cadeia curta (AGCC), implicados em fun\u00e7\u00f5es metab\u00f3licas, imunit\u00e1rias e de sinaliza\u00e7\u00e3o intestinal<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:0,&quot;335551620&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/li>\n \t<li aria-setsize=\"-1\" data-leveltext=\"?\" data-font=\"Symbol\" data-listid=\"14\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559683&quot;:0,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;?&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" data-aria-posinset=\"4\" data-aria-level=\"1\"><span data-contrast=\"auto\"><strong>Oferecem resultados reproduz\u00edveis, \u00e9ticos e custo-efetivos<\/strong>, facilitando a previs\u00e3o de efeitos fisiol\u00f3gicos reais sem necessidade de recorrer inicialmente a estudos in vivo<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:0,&quot;335551620&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/li>\n<\/ul>\n<span data-contrast=\"auto\">Em alguns casos, a aplica\u00e7\u00e3o de<\/span><a href=\"https:\/\/www.ainia.com\/pt\/ensaios-em-digestor-dinamico-de-fermentacao-colonica-modulacao-da-microbiota\/\"><b><span data-contrast=\"none\"> modelos in vitro de digest\u00e3o gastrointestinal e fermenta\u00e7\u00e3o col\u00f3nica <\/span><\/b><\/a><span data-contrast=\"auto\">integra modelos celulares que representam a barreira gastrointestinal, avaliando aspetos cruciais como a permeabilidade intestinal e a resposta imunit\u00e1ria. Utilizando tecnologias avan\u00e7adas como organoides intestinais e dispositivos <\/span><b><span data-contrast=\"none\">organ-on-chip,<\/span><\/b><span data-contrast=\"auto\"> que reproduzem a arquitetura e funcionalidade do epit\u00e9lio intestinal, \u00e9 poss\u00edvel realizar uma an\u00e1lise mais fisiol\u00f3gica das intera\u00e7\u00f5es microbianas e dos efeitos do ingrediente sobre a barreira mucosa. Tudo isto proporciona resultados reprodut\u00edveis, \u00e9ticos e custo-efetivos, facilitando a previs\u00e3o de efeitos fisiol\u00f3gicos reais sem necessidade de recorrer a estudos in vivo.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:0,&quot;335551620&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span>\n\n<span data-contrast=\"auto\">Al\u00e9m disso, o uso destes modelos est\u00e1 alinhado com os princ\u00edpios das <strong>3Rs na experimenta\u00e7\u00e3o animal:<\/strong><\/span><strong>\u00a0<\/strong>\n<ul>\n \t<li aria-setsize=\"-1\" data-leveltext=\"?\" data-font=\"Symbol\" data-listid=\"15\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559683&quot;:0,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;?&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" data-aria-posinset=\"1\" data-aria-level=\"1\"><strong>Substitui\u00e7\u00e3o<\/strong><span data-contrast=\"auto\">: trocando o uso de animais por sistemas in vitro e ex vivo sempre que cientificamente vi\u00e1vel<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:0,&quot;335551620&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n \t<li aria-setsize=\"-1\" data-leveltext=\"?\" data-font=\"Symbol\" data-listid=\"15\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559683&quot;:0,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;?&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" data-aria-posinset=\"2\" data-aria-level=\"1\"><strong>Redu\u00e7\u00e3o<\/strong><span data-contrast=\"auto\"><strong>:<\/strong> permitindo selecionar com maior precis\u00e3o as condi\u00e7\u00f5es e compostos que justifiquem posteriores estudos em modelos animais ou humanos<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:0,&quot;335551620&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n \t<li aria-setsize=\"-1\" data-leveltext=\"?\" data-font=\"Symbol\" data-listid=\"15\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559683&quot;:0,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;?&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" data-aria-posinset=\"3\" data-aria-level=\"1\"><strong>Refinamento<\/strong><span data-contrast=\"auto\"><strong>:<\/strong> melhorando as condi\u00e7\u00f5es experimentais para minimizar o stress e o impacto nos animais, quando o seu uso \u00e9 indispens\u00e1vel<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:0,&quot;335551620&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/li>\n<\/ul>\n<span data-contrast=\"auto\">A <a href=\"https:\/\/www.ainia.com\/pt\/ensaios-em-digestor-dinamico-de-fermentacao-colonica-modulacao-da-microbiota\/\"><strong>modula\u00e7\u00e3o da microbiota do intestino atrav\u00e9s de ingredientes funcionais<\/strong> <\/a>oferece uma abordagem promissora para prevenir ou tratar dist\u00farbios metab\u00f3licos, mas exige evid\u00eancias cient\u00edficas s\u00f3lidas. Neste sentido, os modelos de simula\u00e7\u00e3o digestiva in vitro permitem <strong>a<\/strong><\/span><strong>valiar de forma controlada o comportamento de um ingrediente ao longo do trato gastrointestinal<\/strong><span data-contrast=\"auto\">, o seu impacto sobre a microbiota e a sua capacidade de gerar efeitos ben\u00e9ficos.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:0,&quot;335551620&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span>\n<br><em><strong>Financiado pelo programa de apoios \u00e0 contrata\u00e7\u00e3o de jovens especializados em internacionaliza\u00e7\u00e3o<\/strong><\/em><\/br>\n<img decoding=\"async\" class=\"alignnone size-large wp-image-191111\" src=\"https:\/\/ainia.endesarrollo.pro\/wp-content\/uploads\/Imagen1-7-1024x109.png\" alt=\"\" width=\"1024\" height=\"109\" \/>\n","protected":false},"excerpt":{"rendered":"<p>O aumento vertiginoso da obesidade nas \u00faltimas d\u00e9cadas levou \u00e0 procura de novas explica\u00e7\u00f5es para al\u00e9m da alimenta\u00e7\u00e3o e da inatividade f\u00edsica. Entre os fatores emergentes mais relevantes encontra-se a microbiota do intestino, uma comunidade de microrganismos que habita o trato digestivo e que participa ativamente em processos metab\u00f3licos, imunol\u00f3gicos e digestivos. A sua composi\u00e7\u00e3o, [&hellip;]<\/p>\n","protected":false},"author":390,"featured_media":70872,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[85],"tags":[],"tipo-documento":[],"class_list":["post-70870","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-inovacao-tecnologica"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>O papel da microbiota do intestino na obesidade<\/title>\n<meta name=\"description\" content=\"Explore como a microbiota do intestino influencia a obesidade e como avali\u00e1-la atrav\u00e9s de modelos digestivos in vitro.\" \/>\n<meta name=\"robots\" content=\"noindex, follow\" \/>\n<meta property=\"og:locale\" content=\"pt_PT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"O papel da microbiota do intestino na obesidade\" \/>\n<meta property=\"og:description\" content=\"Explore como a microbiota do intestino influencia a obesidade e como avali\u00e1-la atrav\u00e9s de modelos digestivos in vitro.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ainia.endesarrollo.pro\/pt\/inovacao-tecnologica\/qual-e-o-papel-da-microbiota-do-intestino-no-desenvolvimento-da-obesidade\/\" \/>\n<meta property=\"og:site_name\" content=\"AINIA\" \/>\n<meta property=\"article:published_time\" content=\"2025-07-18T06:52:14+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-05-26T20:36:05+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ainia.endesarrollo.pro\/wp-content\/uploads\/microbiota-intestinal-encabezado-1.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"800\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Lidia Tom\u00e1s\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Lidia Tom\u00e1s\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"6 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/ainia.endesarrollo.pro\\\/pt\\\/inovacao-tecnologica\\\/qual-e-o-papel-da-microbiota-do-intestino-no-desenvolvimento-da-obesidade\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ainia.endesarrollo.pro\\\/pt\\\/inovacao-tecnologica\\\/qual-e-o-papel-da-microbiota-do-intestino-no-desenvolvimento-da-obesidade\\\/\"},\"author\":{\"name\":\"Lidia Tom\u00e1s\",\"@id\":\"https:\\\/\\\/ainia.endesarrollo.pro\\\/pt\\\/#\\\/schema\\\/person\\\/58564432a622f0b2c66902df17d93a42\"},\"headline\":\"Qual \u00e9 o papel da microbiota do intestino no desenvolvimento da obesidade?\",\"datePublished\":\"2025-07-18T06:52:14+00:00\",\"dateModified\":\"2026-05-26T20:36:05+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/ainia.endesarrollo.pro\\\/pt\\\/inovacao-tecnologica\\\/qual-e-o-papel-da-microbiota-do-intestino-no-desenvolvimento-da-obesidade\\\/\"},\"wordCount\":1319,\"publisher\":{\"@id\":\"https:\\\/\\\/ainia.endesarrollo.pro\\\/pt\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/ainia.endesarrollo.pro\\\/pt\\\/inovacao-tecnologica\\\/qual-e-o-papel-da-microbiota-do-intestino-no-desenvolvimento-da-obesidade\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ainia.endesarrollo.pro\\\/wp-content\\\/uploads\\\/microbiota-intestinal-encabezado-1.jpg\",\"articleSection\":[\"Inova\u00e7\u00e3o tecnol\u00f3gica\"],\"inLanguage\":\"pt\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ainia.endesarrollo.pro\\\/pt\\\/inovacao-tecnologica\\\/qual-e-o-papel-da-microbiota-do-intestino-no-desenvolvimento-da-obesidade\\\/\",\"url\":\"https:\\\/\\\/ainia.endesarrollo.pro\\\/pt\\\/inovacao-tecnologica\\\/qual-e-o-papel-da-microbiota-do-intestino-no-desenvolvimento-da-obesidade\\\/\",\"name\":\"O papel da microbiota do intestino na obesidade\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ainia.endesarrollo.pro\\\/pt\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/ainia.endesarrollo.pro\\\/pt\\\/inovacao-tecnologica\\\/qual-e-o-papel-da-microbiota-do-intestino-no-desenvolvimento-da-obesidade\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/ainia.endesarrollo.pro\\\/pt\\\/inovacao-tecnologica\\\/qual-e-o-papel-da-microbiota-do-intestino-no-desenvolvimento-da-obesidade\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ainia.endesarrollo.pro\\\/wp-content\\\/uploads\\\/microbiota-intestinal-encabezado-1.jpg\",\"datePublished\":\"2025-07-18T06:52:14+00:00\",\"dateModified\":\"2026-05-26T20:36:05+00:00\",\"description\":\"Explore como a microbiota do intestino influencia a obesidade e como avali\u00e1-la atrav\u00e9s de modelos digestivos in vitro.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/ainia.endesarrollo.pro\\\/pt\\\/inovacao-tecnologica\\\/qual-e-o-papel-da-microbiota-do-intestino-no-desenvolvimento-da-obesidade\\\/#breadcrumb\"},\"inLanguage\":\"pt\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/ainia.endesarrollo.pro\\\/pt\\\/inovacao-tecnologica\\\/qual-e-o-papel-da-microbiota-do-intestino-no-desenvolvimento-da-obesidade\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"pt\",\"@id\":\"https:\\\/\\\/ainia.endesarrollo.pro\\\/pt\\\/inovacao-tecnologica\\\/qual-e-o-papel-da-microbiota-do-intestino-no-desenvolvimento-da-obesidade\\\/#primaryimage\",\"url\":\"https:\\\/\\\/ainia.endesarrollo.pro\\\/wp-content\\\/uploads\\\/microbiota-intestinal-encabezado-1.jpg\",\"contentUrl\":\"https:\\\/\\\/ainia.endesarrollo.pro\\\/wp-content\\\/uploads\\\/microbiota-intestinal-encabezado-1.jpg\",\"width\":1200,\"height\":800},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/ainia.endesarrollo.pro\\\/pt\\\/inovacao-tecnologica\\\/qual-e-o-papel-da-microbiota-do-intestino-no-desenvolvimento-da-obesidade\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"AINIA\",\"item\":\"https:\\\/\\\/ainia.endesarrollo.pro\\\/pt\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Inova\u00e7\u00e3o tecnol\u00f3gica\",\"item\":\"https:\\\/\\\/ainia.endesarrollo.pro\\\/pt\\\/inovacao-tecnologica\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Qual \u00e9 o papel da microbiota do intestino no desenvolvimento da obesidade?\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/ainia.endesarrollo.pro\\\/pt\\\/#website\",\"url\":\"https:\\\/\\\/ainia.endesarrollo.pro\\\/pt\\\/\",\"name\":\"AINIA\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\\\/\\\/ainia.endesarrollo.pro\\\/pt\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/ainia.endesarrollo.pro\\\/pt\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"pt\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/ainia.endesarrollo.pro\\\/pt\\\/#organization\",\"name\":\"AINIA\",\"url\":\"https:\\\/\\\/ainia.endesarrollo.pro\\\/pt\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"pt\",\"@id\":\"https:\\\/\\\/ainia.endesarrollo.pro\\\/pt\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/ainia.endesarrollo.pro\\\/wp-content\\\/uploads\\\/2025\\\/09\\\/Logo-vector-AINIA.svg\",\"contentUrl\":\"https:\\\/\\\/ainia.endesarrollo.pro\\\/wp-content\\\/uploads\\\/2025\\\/09\\\/Logo-vector-AINIA.svg\",\"width\":148,\"height\":40,\"caption\":\"AINIA\"},\"image\":{\"@id\":\"https:\\\/\\\/ainia.endesarrollo.pro\\\/pt\\\/#\\\/schema\\\/logo\\\/image\\\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/ainia.endesarrollo.pro\\\/pt\\\/#\\\/schema\\\/person\\\/58564432a622f0b2c66902df17d93a42\",\"name\":\"Lidia Tom\u00e1s\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"pt\",\"@id\":\"https:\\\/\\\/ainia.endesarrollo.pro\\\/wp-content\\\/uploads\\\/lidia-tomas-800x800-1.jpg\",\"url\":\"https:\\\/\\\/ainia.endesarrollo.pro\\\/wp-content\\\/uploads\\\/lidia-tomas-800x800-1.jpg\",\"contentUrl\":\"https:\\\/\\\/ainia.endesarrollo.pro\\\/wp-content\\\/uploads\\\/lidia-tomas-800x800-1.jpg\",\"caption\":\"Lidia Tom\u00e1s\"},\"description\":\"Soy Lidia Tom\u00e1s, responsable del equipo de Estudios Precl\u00ednicos con modelos in vitro en AINIA, donde trabajo desde 2005 liderando proyectos de investigaci\u00f3n orientados a la evaluaci\u00f3n de ingredientes funcionales, nutrac\u00e9uticos y cosm\u00e9ticos. Mi especialidad se centra en el desarrollo de modelos avanzados que simulan el tracto gastrointestinal y la fermentaci\u00f3n col\u00f3nica, as\u00ed como \u00f3rganos diana mediante t\u00e9cnicas como cultivo celular, bioimpresi\u00f3n 3D y \u00f3rganos-on-chip. Doctora en Bioqu\u00edmica y Biolog\u00eda Molecular por la Universitat de Val\u00e8ncia, combino una s\u00f3lida formaci\u00f3n cient\u00edfica con experiencia en gesti\u00f3n y transferencia tecnol\u00f3gica. Colaboro con empresas de los sectores alimentario, cosm\u00e9tico y nutrac\u00e9utico para impulsar soluciones innovadoras basadas en evidencia cient\u00edfica. He participado en proyectos nacionales e internacionales como PHARMANOVA, MEAT4FUTURE y PATHWAY-27, y soy miembro activo de redes como INFOGEST, INFOGUT y Food4Life. Adem\u00e1s, imparto formaci\u00f3n especializada en congresos y jornadas sectoriales, contribuyendo a la divulgaci\u00f3n cient\u00edfica y al avance de la investigaci\u00f3n aplicada.\",\"sameAs\":[\"https:\\\/\\\/www.ainia.com\\\/contactar-lidia-tomas\\\/\",\"'=https:\\\/\\\/www.linkedin.com\\\/public-profile\\\/settings?lipi=urnlipaged_flagship3_profile_self_edit_contact-infoSUVPYk6QOSvsEj2ZXWSXQ\"],\"url\":\"https:\\\/\\\/ainia.endesarrollo.pro\\\/pt\\\/author\\\/lidia-tomas-cobos\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"O papel da microbiota do intestino na obesidade","description":"Explore como a microbiota do intestino influencia a obesidade e como avali\u00e1-la atrav\u00e9s de modelos digestivos in vitro.","robots":{"index":"noindex","follow":"follow"},"og_locale":"pt_PT","og_type":"article","og_title":"O papel da microbiota do intestino na obesidade","og_description":"Explore como a microbiota do intestino influencia a obesidade e como avali\u00e1-la atrav\u00e9s de modelos digestivos in vitro.","og_url":"https:\/\/ainia.endesarrollo.pro\/pt\/inovacao-tecnologica\/qual-e-o-papel-da-microbiota-do-intestino-no-desenvolvimento-da-obesidade\/","og_site_name":"AINIA","article_published_time":"2025-07-18T06:52:14+00:00","article_modified_time":"2026-05-26T20:36:05+00:00","og_image":[{"width":1200,"height":800,"url":"https:\/\/ainia.endesarrollo.pro\/wp-content\/uploads\/microbiota-intestinal-encabezado-1.jpg","type":"image\/jpeg"}],"author":"Lidia Tom\u00e1s","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Lidia Tom\u00e1s","Est. reading time":"6 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/ainia.endesarrollo.pro\/pt\/inovacao-tecnologica\/qual-e-o-papel-da-microbiota-do-intestino-no-desenvolvimento-da-obesidade\/#article","isPartOf":{"@id":"https:\/\/ainia.endesarrollo.pro\/pt\/inovacao-tecnologica\/qual-e-o-papel-da-microbiota-do-intestino-no-desenvolvimento-da-obesidade\/"},"author":{"name":"Lidia Tom\u00e1s","@id":"https:\/\/ainia.endesarrollo.pro\/pt\/#\/schema\/person\/58564432a622f0b2c66902df17d93a42"},"headline":"Qual \u00e9 o papel da microbiota do intestino no desenvolvimento da obesidade?","datePublished":"2025-07-18T06:52:14+00:00","dateModified":"2026-05-26T20:36:05+00:00","mainEntityOfPage":{"@id":"https:\/\/ainia.endesarrollo.pro\/pt\/inovacao-tecnologica\/qual-e-o-papel-da-microbiota-do-intestino-no-desenvolvimento-da-obesidade\/"},"wordCount":1319,"publisher":{"@id":"https:\/\/ainia.endesarrollo.pro\/pt\/#organization"},"image":{"@id":"https:\/\/ainia.endesarrollo.pro\/pt\/inovacao-tecnologica\/qual-e-o-papel-da-microbiota-do-intestino-no-desenvolvimento-da-obesidade\/#primaryimage"},"thumbnailUrl":"https:\/\/ainia.endesarrollo.pro\/wp-content\/uploads\/microbiota-intestinal-encabezado-1.jpg","articleSection":["Inova\u00e7\u00e3o tecnol\u00f3gica"],"inLanguage":"pt"},{"@type":"WebPage","@id":"https:\/\/ainia.endesarrollo.pro\/pt\/inovacao-tecnologica\/qual-e-o-papel-da-microbiota-do-intestino-no-desenvolvimento-da-obesidade\/","url":"https:\/\/ainia.endesarrollo.pro\/pt\/inovacao-tecnologica\/qual-e-o-papel-da-microbiota-do-intestino-no-desenvolvimento-da-obesidade\/","name":"O papel da microbiota do intestino na obesidade","isPartOf":{"@id":"https:\/\/ainia.endesarrollo.pro\/pt\/#website"},"primaryImageOfPage":{"@id":"https:\/\/ainia.endesarrollo.pro\/pt\/inovacao-tecnologica\/qual-e-o-papel-da-microbiota-do-intestino-no-desenvolvimento-da-obesidade\/#primaryimage"},"image":{"@id":"https:\/\/ainia.endesarrollo.pro\/pt\/inovacao-tecnologica\/qual-e-o-papel-da-microbiota-do-intestino-no-desenvolvimento-da-obesidade\/#primaryimage"},"thumbnailUrl":"https:\/\/ainia.endesarrollo.pro\/wp-content\/uploads\/microbiota-intestinal-encabezado-1.jpg","datePublished":"2025-07-18T06:52:14+00:00","dateModified":"2026-05-26T20:36:05+00:00","description":"Explore como a microbiota do intestino influencia a obesidade e como avali\u00e1-la atrav\u00e9s de modelos digestivos in vitro.","breadcrumb":{"@id":"https:\/\/ainia.endesarrollo.pro\/pt\/inovacao-tecnologica\/qual-e-o-papel-da-microbiota-do-intestino-no-desenvolvimento-da-obesidade\/#breadcrumb"},"inLanguage":"pt","potentialAction":[{"@type":"ReadAction","target":["https:\/\/ainia.endesarrollo.pro\/pt\/inovacao-tecnologica\/qual-e-o-papel-da-microbiota-do-intestino-no-desenvolvimento-da-obesidade\/"]}]},{"@type":"ImageObject","inLanguage":"pt","@id":"https:\/\/ainia.endesarrollo.pro\/pt\/inovacao-tecnologica\/qual-e-o-papel-da-microbiota-do-intestino-no-desenvolvimento-da-obesidade\/#primaryimage","url":"https:\/\/ainia.endesarrollo.pro\/wp-content\/uploads\/microbiota-intestinal-encabezado-1.jpg","contentUrl":"https:\/\/ainia.endesarrollo.pro\/wp-content\/uploads\/microbiota-intestinal-encabezado-1.jpg","width":1200,"height":800},{"@type":"BreadcrumbList","@id":"https:\/\/ainia.endesarrollo.pro\/pt\/inovacao-tecnologica\/qual-e-o-papel-da-microbiota-do-intestino-no-desenvolvimento-da-obesidade\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"AINIA","item":"https:\/\/ainia.endesarrollo.pro\/pt\/"},{"@type":"ListItem","position":2,"name":"Inova\u00e7\u00e3o tecnol\u00f3gica","item":"https:\/\/ainia.endesarrollo.pro\/pt\/inovacao-tecnologica\/"},{"@type":"ListItem","position":3,"name":"Qual \u00e9 o papel da microbiota do intestino no desenvolvimento da obesidade?"}]},{"@type":"WebSite","@id":"https:\/\/ainia.endesarrollo.pro\/pt\/#website","url":"https:\/\/ainia.endesarrollo.pro\/pt\/","name":"AINIA","description":"","publisher":{"@id":"https:\/\/ainia.endesarrollo.pro\/pt\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/ainia.endesarrollo.pro\/pt\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"pt"},{"@type":"Organization","@id":"https:\/\/ainia.endesarrollo.pro\/pt\/#organization","name":"AINIA","url":"https:\/\/ainia.endesarrollo.pro\/pt\/","logo":{"@type":"ImageObject","inLanguage":"pt","@id":"https:\/\/ainia.endesarrollo.pro\/pt\/#\/schema\/logo\/image\/","url":"https:\/\/ainia.endesarrollo.pro\/wp-content\/uploads\/2025\/09\/Logo-vector-AINIA.svg","contentUrl":"https:\/\/ainia.endesarrollo.pro\/wp-content\/uploads\/2025\/09\/Logo-vector-AINIA.svg","width":148,"height":40,"caption":"AINIA"},"image":{"@id":"https:\/\/ainia.endesarrollo.pro\/pt\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/ainia.endesarrollo.pro\/pt\/#\/schema\/person\/58564432a622f0b2c66902df17d93a42","name":"Lidia Tom\u00e1s","image":{"@type":"ImageObject","inLanguage":"pt","@id":"https:\/\/ainia.endesarrollo.pro\/wp-content\/uploads\/lidia-tomas-800x800-1.jpg","url":"https:\/\/ainia.endesarrollo.pro\/wp-content\/uploads\/lidia-tomas-800x800-1.jpg","contentUrl":"https:\/\/ainia.endesarrollo.pro\/wp-content\/uploads\/lidia-tomas-800x800-1.jpg","caption":"Lidia Tom\u00e1s"},"description":"Soy Lidia Tom\u00e1s, responsable del equipo de Estudios Precl\u00ednicos con modelos in vitro en AINIA, donde trabajo desde 2005 liderando proyectos de investigaci\u00f3n orientados a la evaluaci\u00f3n de ingredientes funcionales, nutrac\u00e9uticos y cosm\u00e9ticos. Mi especialidad se centra en el desarrollo de modelos avanzados que simulan el tracto gastrointestinal y la fermentaci\u00f3n col\u00f3nica, as\u00ed como \u00f3rganos diana mediante t\u00e9cnicas como cultivo celular, bioimpresi\u00f3n 3D y \u00f3rganos-on-chip. Doctora en Bioqu\u00edmica y Biolog\u00eda Molecular por la Universitat de Val\u00e8ncia, combino una s\u00f3lida formaci\u00f3n cient\u00edfica con experiencia en gesti\u00f3n y transferencia tecnol\u00f3gica. Colaboro con empresas de los sectores alimentario, cosm\u00e9tico y nutrac\u00e9utico para impulsar soluciones innovadoras basadas en evidencia cient\u00edfica. He participado en proyectos nacionales e internacionales como PHARMANOVA, MEAT4FUTURE y PATHWAY-27, y soy miembro activo de redes como INFOGEST, INFOGUT y Food4Life. Adem\u00e1s, imparto formaci\u00f3n especializada en congresos y jornadas sectoriales, contribuyendo a la divulgaci\u00f3n cient\u00edfica y al avance de la investigaci\u00f3n aplicada.","sameAs":["https:\/\/www.ainia.com\/contactar-lidia-tomas\/","'=https:\/\/www.linkedin.com\/public-profile\/settings?lipi=urnlipaged_flagship3_profile_self_edit_contact-infoSUVPYk6QOSvsEj2ZXWSXQ"],"url":"https:\/\/ainia.endesarrollo.pro\/pt\/author\/lidia-tomas-cobos\/"}]}},"_links":{"self":[{"href":"https:\/\/ainia.endesarrollo.pro\/pt\/wp-json\/wp\/v2\/posts\/70870","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ainia.endesarrollo.pro\/pt\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ainia.endesarrollo.pro\/pt\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ainia.endesarrollo.pro\/pt\/wp-json\/wp\/v2\/users\/390"}],"replies":[{"embeddable":true,"href":"https:\/\/ainia.endesarrollo.pro\/pt\/wp-json\/wp\/v2\/comments?post=70870"}],"version-history":[{"count":1,"href":"https:\/\/ainia.endesarrollo.pro\/pt\/wp-json\/wp\/v2\/posts\/70870\/revisions"}],"predecessor-version":[{"id":70873,"href":"https:\/\/ainia.endesarrollo.pro\/pt\/wp-json\/wp\/v2\/posts\/70870\/revisions\/70873"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ainia.endesarrollo.pro\/pt\/wp-json\/wp\/v2\/media\/70872"}],"wp:attachment":[{"href":"https:\/\/ainia.endesarrollo.pro\/pt\/wp-json\/wp\/v2\/media?parent=70870"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ainia.endesarrollo.pro\/pt\/wp-json\/wp\/v2\/categories?post=70870"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ainia.endesarrollo.pro\/pt\/wp-json\/wp\/v2\/tags?post=70870"},{"taxonomy":"tipo-documento","embeddable":true,"href":"https:\/\/ainia.endesarrollo.pro\/pt\/wp-json\/wp\/v2\/tipo-documento?post=70870"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}