{"id":70563,"date":"2025-12-04T12:07:04","date_gmt":"2025-12-04T12:07:04","guid":{"rendered":"https:\/\/ainia.endesarrollo.pro\/synthese-des-proteines-role-de-lenzyme-peptidyl-transferase\/"},"modified":"2026-05-26T20:31:35","modified_gmt":"2026-05-26T20:31:35","slug":"synthese-des-proteines-role-de-lenzyme-peptidyl-transferase","status":"publish","type":"post","link":"https:\/\/ainia.endesarrollo.pro\/fr\/innovation-technologique\/synthese-des-proteines-role-de-lenzyme-peptidyl-transferase\/","title":{"rendered":"Synth\u00e8se des prot\u00e9ines : r\u00f4le de l\u0092enzyme peptidyl-transf\u00e9rase"},"content":{"rendered":"\n<span data-contrast=\"none\"><span class=\"TextRun SCXW41880406 BCX8\" lang=\"ES-ES\" xml_lang=\"ES-ES\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW41880406 BCX8\"><span class=\"TextRun SCXW194446391 BCX8\" lang=\"ES-ES\" xml_lang=\"ES-ES\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW194446391 BCX8\"><span class=\"TextRun SCXW1005685 BCX8\" lang=\"ES-ES\" xml_lang=\"ES-ES\" data-contrast=\"auto\"><span class=\"NormalTextRun SpellingErrorV2Themed SCXW1005685 BCX8\"><\/span><\/span><\/span><\/span><\/span><\/span><\/span><span data-contrast=\"auto\">La\u00a0<\/span><b><span data-contrast=\"auto\">synth\u00e8se\u00a0des\u00a0prot\u00e9ines<\/span><\/b><span data-contrast=\"auto\">\u00a0est\u00a0l\u0092un\u00a0des\u00a0processus\u00a0m\u00e9taboliques\u00a0les plus\u00a0intensifs\u00a0et\u00a0finement\u00a0r\u00e9gul\u00e9s\u00a0de la\u00a0cellule. Au\u00a0c\u009cur\u00a0de\u00a0cette\u00a0machinerie\u00a0se\u00a0trouve\u00a0l\u0092<\/span><b><span data-contrast=\"auto\">enzyme\u00a0peptidyl-transf\u00e9rase<\/span><\/b><span data-contrast=\"auto\">, centre\u00a0catalytique\u00a0du\u00a0ribosome\u00a0charg\u00e9\u00a0de\u00a0cr\u00e9er\u00a0la liaison\u00a0peptidique\u00a0qui\u00a0unit\u00a0les acides\u00a0amin\u00e9s\u00a0et\u00a0donne\u00a0naissance\u00a0\u00e0 la\u00a0cha\u00eene\u00a0polypeptidique. Dans\u00a0cet\u00a0article,\u00a0nous\u00a0passons\u00a0en\u00a0revue\u00a0le\u00a0d\u00e9roul\u00e9\u00a0de la\u00a0traduction,\u00a0l\u0092importance\u00a0de\u00a0cette\u00a0enzyme\u00a0et la\u00a0mani\u00e8re\u00a0dont\u00a0ce savoir\u00a0peut\u00a0\u00eatre\u00a0exploit\u00e9\u00a0en\u00a0biotechnologie\u00a0et en\u00a0formulation\u00a0d\u0092ingr\u00e9dients.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span>\n<h2 aria-level=\"2\"><b><span data-contrast=\"none\">Qu\u0092est-ce que la\u00a0synth\u00e8se\u00a0des\u00a0prot\u00e9ines\u00a0?<\/span><\/b><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;134245418&quot;:true,&quot;134245529&quot;:true,&quot;335559738&quot;:299,&quot;335559739&quot;:299}\">\u00a0<\/span><\/h2>\n<span data-contrast=\"auto\">La\u00a0<\/span><b><span data-contrast=\"auto\">synth\u00e8se\u00a0des\u00a0prot\u00e9ines<\/span><\/b><span data-contrast=\"auto\">\u00a0correspond\u00a0\u00e0\u00a0l\u0092assemblage\u00a0s\u00e9quentiel\u00a0d\u0092acides\u00a0amin\u00e9s\u00a0sur un\u00a0ribosome\u00a0\u00e0 partir de\u00a0l\u0092information\u00a0cod\u00e9e\u00a0dans\u00a0un ARNm.\u00a0Elle\u00a0comprend\u00a0trois\u00a0phases\u00a0principales :<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span>\n<ul>\n \t<li><b><span data-contrast=\"auto\">Initiation\u00a0:<\/span><\/b><span data-contrast=\"auto\">\u00a0le\u00a0ribosome\u00a0reconna\u00eet\u00a0le site de\u00a0d\u00e9part\u00a0sur\u00a0l\u0092ARNm,\u00a0l\u0092ARNt\u00a0initiateur\u00a0se\u00a0positionne\u00a0sur le site P et le cadre de\u00a0lecture\u00a0est\u00a0\u00e9tabli.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/li>\n \t<li><b><span data-contrast=\"auto\">\u00c9longation\u00a0:<\/span><\/b><span data-contrast=\"auto\">\u00a0des\u00a0aminoacyl-ARNt\u00a0entrent\u00a0s\u00e9quentiellement\u00a0sur le site A.\u00a0L\u0092<\/span><b><span data-contrast=\"auto\">enzyme\u00a0peptidyl-transf\u00e9rase<\/span><\/b><span data-contrast=\"auto\">\u00a0catalyse\u00a0la\u00a0formation\u00a0de la liaison\u00a0peptidique\u00a0entre le\u00a0peptide\u00a0situ\u00e9 sur le site P et\u00a0l\u0092acide\u00a0amin\u00e9 du site A.\u00a0Apr\u00e8s\u00a0chaque\u00a0r\u00e9action, le\u00a0ribosome\u00a0<\/span><b><span data-contrast=\"auto\">transloque<\/span><\/b><span data-contrast=\"auto\">\u00a0d\u0092un\u00a0codon\u00a0et le\u00a0peptide\u00a0naissant\u00a0passe\u00a0de A\u00a0vers\u00a0P.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/li>\n \t<li><b><span data-contrast=\"auto\">Terminaison\u00a0:<\/span><\/b><span data-contrast=\"auto\">\u00a0\u00e0\u00a0l\u0092arriv\u00e9e\u00a0sur un\u00a0codon\u00a0stop, les\u00a0<\/span><b><span data-contrast=\"auto\">facteurs\u00a0de\u00a0lib\u00e9ration<\/span><\/b><span data-contrast=\"auto\">\u00a0provoquent\u00a0l\u0092hydrolyse\u00a0du\u00a0peptidyl-ARNt, la\u00a0prot\u00e9ine\u00a0est\u00a0lib\u00e9r\u00e9e\u00a0et le\u00a0ribosome\u00a0est\u00a0recycl\u00e9.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/li>\n<\/ul>\n<h2 aria-level=\"2\"><b><span data-contrast=\"none\">Importance\u00a0de\u00a0l\u0092enzyme\u00a0peptidyl-transf\u00e9rase<\/span><\/b><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;134245418&quot;:true,&quot;134245529&quot;:true,&quot;335559738&quot;:299,&quot;335559739&quot;:299}\">\u00a0<\/span><\/h2>\n<span data-contrast=\"auto\">L\u0092<\/span><b><span data-contrast=\"auto\">enzyme\u00a0peptidyl-transf\u00e9rase<\/span><\/b><span data-contrast=\"auto\">\u00a0correspond\u00a0\u00e0 une\u00a0activit\u00e9\u00a0catalytique\u00a0de\u00a0l\u0092ARN\u00a0ribosomique\u00a0localis\u00e9e\u00a0dans\u00a0la grande\u00a0sous-unit\u00e9. Sa\u00a0fonction\u00a0centrale\u00a0est\u00a0de\u00a0former\u00a0la\u00a0<\/span><b><span data-contrast=\"auto\">liaison\u00a0peptidique<\/span><\/b><span data-contrast=\"auto\">\u00a0via\u00a0une\u00a0r\u00e9action\u00a0de\u00a0<\/span><b><span data-contrast=\"auto\">transest\u00e9rification<\/span><\/b><span data-contrast=\"auto\"> entre le\u00a0groupe\u00a0?-amine de\u00a0l\u0092aminoacyl-ARNt du site A et le\u00a0carbonyle\u00a0du\u00a0peptidyl-ARNt du site P.\u00a0<\/span><b><span data-contrast=\"auto\">Pourquoi\u00a0est-elle\u00a0d\u00e9terminante\u00a0?<\/span><\/b><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span>\n<ul>\n \t<li><b><span data-contrast=\"auto\">Vitesse et\u00a0productivit\u00e9\u00a0:<\/span><\/b><span data-contrast=\"auto\">\u00a0elle\u00a0fixe\u00a0le\u00a0taux\u00a0d\u0092\u00e9longation\u00a0et, par\u00a0cons\u00e9quent, le\u00a0rendement\u00a0prot\u00e9ique\u00a0de la\u00a0cellule\u00a0ou\u00a0du\u00a0bioproc\u00e9d\u00e9.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/li>\n \t<li><b><span data-contrast=\"auto\">Fid\u00e9lit\u00e9\u00a0indirecte :<\/span><\/b><span data-contrast=\"auto\">\u00a0m\u00eame\u00a0si la\u00a0reconnaissance\u00a0codon-anticodon\u00a0a\u00a0lieu\u00a0dans\u00a0la\u00a0petite\u00a0sous-unit\u00e9, la\u00a0g\u00e9om\u00e9trie\u00a0du\u00a0<\/span><b><span data-contrast=\"auto\">peptidyl\u00a0transferase\u00a0center (PTC)<\/span><\/b><span data-contrast=\"auto\">\u00a0favorise\u00a0les\u00a0substrats\u00a0correctement\u00a0appari\u00e9s\u00a0et\u00a0d\u00e9courage\u00a0les\u00a0interm\u00e9diaires\u00a0non\u00a0productifs.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/li>\n \t<li><b><span data-contrast=\"auto\">\u00c9volution\u00a0et\u00a0universalit\u00e9\u00a0:<\/span><\/b><span data-contrast=\"auto\">\u00a0la\u00a0conservation\u00a0structurelle\u00a0du PTC\u00a0souligne\u00a0son\u00a0anciennet\u00e9\u00a0\u00e9volutive\u00a0et son\u00a0r\u00f4le\u00a0de\u00a0noyau\u00a0de la\u00a0machinerie\u00a0de\u00a0traduction.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/li>\n<\/ul>\n<span data-contrast=\"auto\">En\u00a0optimisant\u00a0cette\u00a0\u00e9tape\u00a0cl\u00e9\u00a0de la\u00a0<\/span><b><span data-contrast=\"auto\">synth\u00e8se\u00a0des\u00a0prot\u00e9ines<\/span><\/b><span data-contrast=\"auto\">,\u00a0nous\u00a0am\u00e9liorons\u00a0l\u0092efficacit\u00e9\u00a0et la\u00a0qualit\u00e9\u00a0de\u00a0prot\u00e9ines,\u00a0peptides\u00a0et\u00a0enzymes\u00a0qui\u00a0ouvrent\u00a0des\u00a0voies\u00a0s\u00e9lectives\u00a0et durables\u00a0vers\u00a0des\u00a0<\/span><strong><a href=\"https:\/\/www.ainia.com\/fr\/ingredients-composes-bioactifs\/\">ingr\u00e9dients\u00a0et\u00a0compos\u00e9s\u00a0bioactifs<\/a><\/strong><span data-contrast=\"auto\"> \u00e0 forte valeur ajout\u00e9e.<\/span>\n<h3 aria-level=\"2\"><strong>Synth\u00e8se\u00a0des\u00a0prot\u00e9ines\u00a0:\u00a0m\u00e9canisme\u00a0catalytique\u00a0<\/strong><\/h3>\n<ol>\n \t<li><b><span data-contrast=\"auto\">Accommodation\u00a0:<\/span><\/b><span data-contrast=\"auto\">\u00a0l\u0092aminoacyl-ARNt\u00a0correctement\u00a0appari\u00e9\u00a0sur le site A pivote et se place\u00a0avec\u00a0pr\u00e9cision.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/li>\n \t<li><b><span data-contrast=\"auto\">Activation\u00a0nucl\u00e9ophile\u00a0:<\/span><\/b><span data-contrast=\"auto\">\u00a0le\u00a0groupe\u00a0?-amine\u00a0de\u00a0l\u0092ARNt\u00a0du site A\u00a0agit\u00a0comme\u00a0nucl\u00e9ophile\u00a0et\u00a0attaque\u00a0le\u00a0carbonyle\u00a0de\u00a0l\u0092ester\u00a0port\u00e9 par le\u00a0peptidyl-ARNt.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/li>\n \t<li><b><span data-contrast=\"auto\">\u00c9tat\u00a0de\u00a0transition\u00a0:<\/span><\/b><span data-contrast=\"auto\">\u00a0le PTC\u00a0stabilise\u00a0l\u0092interm\u00e9diaire\u00a0t\u00e9tra\u00e9drique\u00a0gr\u00e2ce\u00a0\u00e0 des\u00a0r\u00e9seaux\u00a0de\u00a0liaisons\u00a0hydrog\u00e8ne\u00a0et \u00e0 un\u00a0pr\u00e9-positionnement\u00a0st\u00e9rique\u00a0; des\u00a0ions\u00a0tels\u00a0que\u00a0<\/span><b><span data-contrast=\"auto\">Mg\u00b2?<\/span><\/b><span data-contrast=\"auto\">\u00a0contribuent\u00a0\u00e0\u00a0cette\u00a0stabilisation.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/li>\n \t<li><b><span data-contrast=\"auto\">R\u00e9solution\u00a0:<\/span><\/b><span data-contrast=\"auto\">\u00a0le\u00a0peptide\u00a0est\u00a0transf\u00e9r\u00e9\u00a0sur\u00a0l\u0092ARNt\u00a0du site A,\u00a0l\u0092ARNt\u00a0d\u00e9sacyl\u00e9\u00a0du site P\u00a0est\u00a0lib\u00e9r\u00e9\u00a0et le\u00a0ribosome\u00a0transloque.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/li>\n \t<li><b><span data-contrast=\"auto\">Cycle\u00a0:<\/span><\/b><span data-contrast=\"auto\">\u00a0la\u00a0r\u00e9p\u00e9tition\u00a0du\u00a0cycle\u00a0d\u0092\u00e9longation\u00a0allonge\u00a0la\u00a0cha\u00eene\u00a0jusqu\u0092au\u00a0codon\u00a0stop.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/li>\n<\/ol>\n<h3 aria-level=\"2\"><strong>Structure\u00a0et bases\u00a0mol\u00e9culaires\u00a0:\u00a0enzyme\u00a0peptidyl-transf\u00e9rase\u00a0<\/strong><\/h3>\n<ul>\n \t<li><b><span data-contrast=\"auto\">Architecture\u00a0du\u00a0PTC :<\/span><\/b><span data-contrast=\"auto\">\u00a0cavit\u00e9\u00a0d\u0092ARNr\u00a0dens\u00e9ment\u00a0structur\u00e9e\u00a0o\u00f9\u00a0convergent\u00a0les\u00a0extr\u00e9mit\u00e9s\u00a03\u0092 des ARNt des sites P et A. Les\u00a0<\/span><b><span data-contrast=\"auto\">bases de\u00a0l\u0092ARNr<\/span><\/b><span data-contrast=\"auto\">\u00a0d\u00e9limitent\u00a0l\u0092environnement\u00a0catalytique.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/li>\n \t<li><b><span data-contrast=\"auto\">Tunnel\u00a0de\u00a0sortie\u00a0:<\/span><\/b><span data-contrast=\"auto\">\u00a0canal\u00a0guidant\u00a0la\u00a0cha\u00eene\u00a0naissante\u00a0vers\u00a0l\u0092ext\u00e9rieur\u00a0; son\u00a0micro-environnement\u00a0influence\u00a0les\u00a0<\/span><b><span data-contrast=\"auto\">pauses\u00a0traductionnelles<\/span><\/b><span data-contrast=\"auto\">\u00a0et\u00a0l\u0092interaction\u00a0avec\u00a0les\u00a0<\/span><b><span data-contrast=\"auto\">macrolides<\/span><\/b><span data-contrast=\"auto\">.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/li>\n \t<li><b><span data-contrast=\"auto\">Conservation\u00a0et\u00a0variation\u00a0:<\/span><\/b><span data-contrast=\"auto\">\u00a0la\u00a0topologie\u00a0du PTC\u00a0est\u00a0fortement\u00a0conserv\u00e9e\u00a0chez\u00a0les\u00a0bact\u00e9ries,\u00a0arch\u00e9es,\u00a0eucaryotes\u00a0et\u00a0au\u00a0sein\u00a0des\u00a0ribosomes\u00a0mitochondriaux\u00a0; des\u00a0diff\u00e9rences\u00a0subtiles\u00a0expliquent\u00a0la\u00a0<\/span><b><span data-contrast=\"auto\">s\u00e9lectivit\u00e9\u00a0des\u00a0antibiotiques<\/span><\/b><span data-contrast=\"auto\">\u00a0et les\u00a0ph\u00e9nom\u00e8nes\u00a0de\u00a0<\/span><b><span data-contrast=\"auto\">r\u00e9sistance<\/span><\/b><span data-contrast=\"auto\">.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/li>\n<\/ul>\n<h2 aria-level=\"2\"><strong>Applications\u00a0pratiques\u00a0:\u00a0formulation\u00a0et\u00a0proc\u00e9d\u00e9s\u00a0<\/strong><\/h2>\n<span data-contrast=\"auto\">Un\u00a0contr\u00f4le\u00a0pr\u00e9cis\u00a0de la\u00a0<\/span><b><span data-contrast=\"auto\">synth\u00e8se\u00a0des\u00a0prot\u00e9ines<\/span><\/b><span data-contrast=\"auto\">\u00a0et, en\u00a0particulier, de\u00a0l\u0092activit\u00e9\u00a0de\u00a0l\u0092<\/span><b><span data-contrast=\"auto\">enzyme\u00a0peptidyl-transf\u00e9rase<\/span><\/b><span data-contrast=\"auto\">\u00a0au\u00a0cours\u00a0de\u00a0l\u0092\u00e9longation, impacte\u00a0directement\u00a0la\u00a0<\/span><b><span data-contrast=\"auto\">quantit\u00e9<\/span><\/b><span data-contrast=\"auto\">, la\u00a0<\/span><b><span data-contrast=\"auto\">puret\u00e9<\/span><\/b><span data-contrast=\"auto\">\u00a0et la\u00a0<\/span><b><span data-contrast=\"auto\">fonctionnalit\u00e9<\/span><\/b><span data-contrast=\"auto\">\u00a0des\u00a0prot\u00e9ines\u00a0et\u00a0peptides\u00a0utilis\u00e9s\u00a0pour\u00a0d\u00e9velopper\u00a0des\u00a0<\/span><strong><a href=\"https:\/\/www.ainia.com\/fr\/ingredients-composes-bioactifs\/\">ingr\u00e9dients\u00a0et\u00a0compos\u00e9s\u00a0bioactifs<\/a><\/strong><span data-contrast=\"auto\">\u00a0\u00e0 haute\u00a0valeur\u00a0ajout\u00e9e.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span>\n\n<img fetchpriority=\"high\" decoding=\"async\" class=\"alignnone size-large wp-image-120127\" src=\"https:\/\/ainia.endesarrollo.pro\/wp-content\/uploads\/Cabecera_Desarrollo_ingredientes_compuestos_bioactivos_cosmetica_higiene-1024x683.jpg\" alt=\"Compuestos bioactivos\" width=\"1024\" height=\"683\" \/>\n\n<span data-contrast=\"auto\"><span class=\"NormalTextRun SCXW5023827 BCX8\">Financ\u00e9<\/span><span class=\"NormalTextRun SCXW5023827 BCX8\">\u00a0par le\u00a0<\/span><span class=\"NormalTextRun SCXW5023827 BCX8\">programme<\/span><span class=\"NormalTextRun SCXW5023827 BCX8\">\u00a0<\/span><span class=\"NormalTextRun SCXW5023827 BCX8\">d\u0092aides<\/span><span class=\"NormalTextRun SCXW5023827 BCX8\">\u00a0\u00e0\u00a0<\/span><span class=\"NormalTextRun SCXW5023827 BCX8\">l\u0092embauche<\/span><span class=\"NormalTextRun SCXW5023827 BCX8\">\u00a0de\u00a0<\/span><span class=\"NormalTextRun SCXW5023827 BCX8\">jeunes<\/span><span class=\"NormalTextRun SCXW5023827 BCX8\">\u00a0<\/span><span class=\"NormalTextRun SCXW5023827 BCX8\">professionnels<\/span><span class=\"NormalTextRun SCXW5023827 BCX8\">\u00a0<\/span><span class=\"NormalTextRun SCXW5023827 BCX8\">sp\u00e9cialis\u00e9s<\/span><span class=\"NormalTextRun SCXW5023827 BCX8\">\u00a0en\u00a0<\/span><span class=\"NormalTextRun SCXW5023827 BCX8\">internationalisation<\/span><\/span>\n\n<span data-contrast=\"auto\"><img decoding=\"async\" class=\"alignnone size-large wp-image-191113\" src=\"https:\/\/ainia.endesarrollo.pro\/wp-content\/uploads\/Imagen1-7-1024x109.png\" alt=\"\" width=\"1024\" height=\"109\" \/><\/span>\n","protected":false},"excerpt":{"rendered":"<p>La\u00a0synth\u00e8se\u00a0des\u00a0prot\u00e9ines\u00a0est\u00a0l\u0092un\u00a0des\u00a0processus\u00a0m\u00e9taboliques\u00a0les plus\u00a0intensifs\u00a0et\u00a0finement\u00a0r\u00e9gul\u00e9s\u00a0de la\u00a0cellule. Au\u00a0c\u009cur\u00a0de\u00a0cette\u00a0machinerie\u00a0se\u00a0trouve\u00a0l\u0092enzyme\u00a0peptidyl-transf\u00e9rase, centre\u00a0catalytique\u00a0du\u00a0ribosome\u00a0charg\u00e9\u00a0de\u00a0cr\u00e9er\u00a0la liaison\u00a0peptidique\u00a0qui\u00a0unit\u00a0les acides\u00a0amin\u00e9s\u00a0et\u00a0donne\u00a0naissance\u00a0\u00e0 la\u00a0cha\u00eene\u00a0polypeptidique. Dans\u00a0cet\u00a0article,\u00a0nous\u00a0passons\u00a0en\u00a0revue\u00a0le\u00a0d\u00e9roul\u00e9\u00a0de la\u00a0traduction,\u00a0l\u0092importance\u00a0de\u00a0cette\u00a0enzyme\u00a0et la\u00a0mani\u00e8re\u00a0dont\u00a0ce savoir\u00a0peut\u00a0\u00eatre\u00a0exploit\u00e9\u00a0en\u00a0biotechnologie\u00a0et en\u00a0formulation\u00a0d\u0092ingr\u00e9dients.\u00a0 Qu\u0092est-ce que la\u00a0synth\u00e8se\u00a0des\u00a0prot\u00e9ines\u00a0?\u00a0 La\u00a0synth\u00e8se\u00a0des\u00a0prot\u00e9ines\u00a0correspond\u00a0\u00e0\u00a0l\u0092assemblage\u00a0s\u00e9quentiel\u00a0d\u0092acides\u00a0amin\u00e9s\u00a0sur un\u00a0ribosome\u00a0\u00e0 partir de\u00a0l\u0092information\u00a0cod\u00e9e\u00a0dans\u00a0un ARNm.\u00a0Elle\u00a0comprend\u00a0trois\u00a0phases\u00a0principales :\u00a0 Initiation\u00a0:\u00a0le\u00a0ribosome\u00a0reconna\u00eet\u00a0le site de\u00a0d\u00e9part\u00a0sur\u00a0l\u0092ARNm,\u00a0l\u0092ARNt\u00a0initiateur\u00a0se\u00a0positionne\u00a0sur le site P et le cadre de\u00a0lecture\u00a0est\u00a0\u00e9tabli.\u00a0 \u00c9longation\u00a0:\u00a0des\u00a0aminoacyl-ARNt\u00a0entrent\u00a0s\u00e9quentiellement\u00a0sur le site A.\u00a0L\u0092enzyme\u00a0peptidyl-transf\u00e9rase\u00a0catalyse\u00a0la\u00a0formation\u00a0de la liaison\u00a0peptidique\u00a0entre le\u00a0peptide\u00a0situ\u00e9 sur le site P et\u00a0l\u0092acide\u00a0amin\u00e9 du site A.\u00a0Apr\u00e8s\u00a0chaque\u00a0r\u00e9action, le\u00a0ribosome\u00a0transloque\u00a0d\u0092un\u00a0codon\u00a0et le\u00a0peptide\u00a0naissant\u00a0passe\u00a0de A\u00a0vers\u00a0P.\u00a0 Terminaison\u00a0:\u00a0\u00e0\u00a0l\u0092arriv\u00e9e\u00a0sur un\u00a0codon\u00a0stop, les\u00a0facteurs\u00a0de\u00a0lib\u00e9ration\u00a0provoquent\u00a0l\u0092hydrolyse\u00a0du\u00a0peptidyl-ARNt, la\u00a0prot\u00e9ine\u00a0est\u00a0lib\u00e9r\u00e9e\u00a0et le\u00a0ribosome\u00a0est\u00a0recycl\u00e9.\u00a0 [&hellip;]<\/p>\n","protected":false},"author":555,"featured_media":70564,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[86],"tags":[],"tipo-documento":[],"class_list":["post-70563","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-innovation-technologique"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Synth\u00e8se des prot\u00e9ines : r\u00f4le de l\u0092enzyme peptidyl-transf\u00e9rase<\/title>\n<meta name=\"description\" content=\"Comprenez comment la peptidyl-transf\u00e9rase, l\u0092enzyme de la synth\u00e8se des prot\u00e9ines, catalyse la formation de la liaison peptidique et pilote la traduction.\" \/>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" 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