{"id":70409,"date":"2020-12-23T07:28:34","date_gmt":"2020-12-23T07:28:34","guid":{"rendered":"https:\/\/ainia.endesarrollo.pro\/processes-with-supercritical-co2-and-encapsulation-expanding-possibilities\/"},"modified":"2026-05-26T20:30:09","modified_gmt":"2026-05-26T20:30:09","slug":"processes-with-supercritical-co2-and-encapsulation-expanding-possibilities","status":"publish","type":"post","link":"https:\/\/ainia.endesarrollo.pro\/fr\/non-classifiee\/processes-with-supercritical-co2-and-encapsulation-expanding-possibilities\/","title":{"rendered":"Proc\u00e9d\u00e9s au CO2 supercritique et encapsulation : multiplier les opportunit\u00e9s"},"content":{"rendered":"\n
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Le CO2 supercritique peut \u00eatre utilis\u00e9 non seulement pour obtenir des extraits adapt\u00e9s \u00e0 l’encapsulation, mais aussi \u00e0 d’autres \u00e9tapes du processus, telles que la g\u00e9n\u00e9ration de particules, l’impr\u00e9gnation de mat\u00e9riaux, la r\u00e9duction de la charge microbienne, et bien plus encore.<\/p>\n<\/blockquote>\n

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Les pr\u00e9f\u00e9rences des consommateurs et les attentes de l’industrie incluent la recherche de produits plus naturels et plus s\u00f9rs, afin d’am\u00e9liorer la qualit\u00e9 de vie dans des domaines tels que l’alimentation, la sant\u00e9 et la cosm\u00e9tique. L’encapsulation de diverses substances peut jouer un r\u00f4le positif dans cette d\u00e9marche, et la technologie au CO2 supercritiqu<\/strong>e<\/a> offre de nombreuses opportunit\u00e9s pour des processus innovants et durables.<\/p>\nLa recherche d’alternatives plus durables<\/strong> pour r\u00e9pondre aux d\u00e9fis technologiques et soci\u00e9taux n’est plus une simple tendance marginale, mais une n\u00e9cessit\u00e9 reconnue par la soci\u00e9t\u00e9 et les institutions. Des initiatives telles que les Objectifs de d\u00e9veloppement durable (ODD) ou le Pacte vert pour l’Europe, qui constitue la base du Plan d’action pour l’\u00e9conomie circulaire adopt\u00e9 en 2020, en sont la preuve.\n\nLes consommateurs et les industriels cherchent des produits plus naturels et s\u00fbrs pour am\u00e9liorer la qualit\u00e9 de vie, tout en visant \u00e0 rendre leur exp\u00e9rience d’utilisation aussi agr\u00e9able que possible. L’int\u00e9r\u00eat croissant pour la sant\u00e9 personnelle, celle des \u00eatres vivants et de l’environnement stimule l’attention port\u00e9e non seulement aux mati\u00e8res premi\u00e8res et aux ingr\u00e9dients d\u00e9riv\u00e9s, mais aussi aux m\u00e9thodes de transformation. Cette tendance est particuli\u00e8rement marqu\u00e9e dans l’agroalimentaire et s’\u00e9tend \u00e0 la cosm\u00e9tique.\n\nCela explique l’int\u00e9r\u00eat croissant pour la protection des substances bioactives fragiles afin de pr\u00e9server leur fonctionnalit\u00e9 (extraits fonctionnels, microorganismes, cellules) ou pour am\u00e9liorer leurs propri\u00e9t\u00e9s afin d’en faciliter l’usage (par exemple, r\u00e9duire l’impact organoleptique). L’encapsulation, \u00e0 l’\u00e9chelle macro, micro ou nanom\u00e9trique, peut apporter des r\u00e9ponses positives. Dans ce contexte, la technologie des fluides supercritiques, et en particulier le CO2 supercritique<\/strong>, offre de nombreuses possibilit\u00e9s pour des processus innovants et durables.\n\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

CO2 supercritique : un outil polyvalent pour l’innovation en encapsulation<\/strong><\/h2>\nLe CO2 supercritique<\/strong> est le fluide supercritique le plus utilis\u00e9, gr\u00e2ce \u00e0 ses propri\u00e9t\u00e9s avantageuses dans ces conditions (forte diffusivit\u00e9, grand pouvoir de dissolution, non toxique, non inflammable, non explosif, \u00e9conomique, largement disponible, etc.).\n\nSa polyvalence a stimul\u00e9 l’expansion des recherches et des applications ces derni\u00e8res d\u00e9cennies, comme en t\u00e9moignent les publications scientifiques et technologiques en hausse constante.\n\nDans le cadre de l’encapsulation<\/strong>, le CO2 supercritique permet d’agir sur diff\u00e9rentes \u00e9tapes du processus, offrant des opportunit\u00e9s vari\u00e9es, comme l’illustrent plusieurs exemples r\u00e9cents.\n

Extraction d’extraits pour l’encapsulation<\/strong><\/h3>\n

Le CO2 supercritique<\/strong> est un excellent solvant pour les substances lipophiles non polaires. Il est utilis\u00e9 non seulement pour le d\u00e9graissage et l’obtention de prot\u00e9ines, mais aussi pour produire des extraits de haute qualit\u00e9. Ces proc\u00e9d\u00e9s d’extraction sont r\u00e9alis\u00e9s sans oxyg\u00e8ne et \u00e0 temp\u00e9rature mod\u00e9r\u00e9e, pr\u00e9servant ainsi les propri\u00e9t\u00e9s fonctionnelles ou organoleptiques des extraits par rapport aux m\u00e9thodes traditionnelles utilisant des solvants organiques.<\/p>\nDes exemples d’applications industrielles (cosm\u00e9tiques, parfums) coexistent avec des recherches visant \u00e0 explorer de nouvelles voies, notamment l’interaction avec d’autres composants. Une \u00e9tude de 2020 a mis en \u00e9vidence l’utilisation du CO2 supercritique pour extraire des pelures d’oignon un extrait antioxydant riche en querc\u00e9tine, ainsi que son interaction avec la ?-lactoglobuline comme potentiel vecteur.\n

Production de particules micro\/nano-encapsul\u00e9es<\/strong><\/h3>\n

La technologie au CO2 supercritique<\/strong> permet aussi la micronisation ou l’encapsulation de substances<\/a>,<\/strong> en particulier \u00e0 l’\u00e9chelle microm\u00e9trique. Les proc\u00e9d\u00e9s exploitant les propri\u00e9t\u00e9s du CO2 supercritique pour g\u00e9n\u00e9rer des particules sont multiples et repr\u00e9sentent un domaine d’innovation majeur.<\/p>\nSelon la nature des substances, du rev\u00eatement, de l’application vis\u00e9e et des objectifs (am\u00e9lioration de la biodisponibilit\u00e9, contr\u00f4le de la lib\u00e9ration, etc.), il est essentiel d’\u00e9valuer les technologies appropri\u00e9es \u00e0 base de CO2 supercritique.\n\nDe nombreux exemples ont \u00e9merg\u00e9 en 2020 : vitamines (E, C, riboflavine, tocoph\u00e9rol), extraits naturels (a\u00e7a\u00ef, poivre rose, huiles essentielles), compos\u00e9s bioactifs (curcuma, disulfirame antitumoral) ou encore principes actifs pharmaceutiques (amoxicilline, anti-inflammatoires, coenzyme Q10, arginine).\n\nCes proc\u00e9d\u00e9s reposent soit sur la solubilisation dans le CO2 supercritique suivie d’une pr\u00e9cipitation (ex. : RESS), soit sur l’utilisation du CO2 supercritique comme anti-solvant (ex. : SAS, GAS, PCA, PGSS, DELOS, SFEE, ASES), avec une grande diversit\u00e9 d’applications.\n\nL’efficacit\u00e9 de ces proc\u00e9d\u00e9s d\u00e9pend aussi de l’\u00e9quipement utilis\u00e9 (buses, syst\u00e8mes de collecte, m\u00e9langeurs, etc.), ce qui explique le d\u00e9veloppement d’innovations sp\u00e9cifiques.\n

Impr\u00e9gnation de supports et encapsul\u00e9s avec CO2 supercritique<\/strong><\/h3>\n

Gr\u00e2ce \u00e0 sa forte diffusivit\u00e9, le CO2 supercritique permet d’impr\u00e9gner divers mat\u00e9riaux<\/strong>,<\/a> conf\u00e9rant des fonctionnalit\u00e9s suppl\u00e9mentaires.<\/p>\nIl est utilis\u00e9 pour ins\u00e9rer des substances dans des particules pr\u00e9alablement form\u00e9es<\/strong>. Par exemple, une \u00e9tude a montr\u00e9 l’impr\u00e9gnation de microparticules de soja avec de l’huile de chia, prot\u00e9geant cette derni\u00e8re contre l’oxydation et contr\u00f4lant sa lib\u00e9ration dans le tractus gastro-intestinal.\n

Post-traitement d’encapsul\u00e9s : d\u00e9solvatation, s\u00e9chage, st\u00e9rilisation<\/strong><\/h3>\nDans certains cas, des proc\u00e9d\u00e9s d’encapsulation impliquent des solvants organiques, n\u00e9cessitant des \u00e9tapes de purification. Le CO2 supercritique peut \u00eatre utilis\u00e9 pour \u00e9liminer ces r\u00e9sidus, comme le montre une \u00e9tude de 2020 ayant retir\u00e9 99 % du dichlorom\u00e9thane de microsph\u00e8res de PLGA contenant de la risp\u00e9ridone.\n\nDans d’autres cas, la st\u00e9rilisation des dispositifs encapsul\u00e9s est cruciale, notamment pour des applications biom\u00e9dicales. Une recherche r\u00e9cente a d\u00e9montr\u00e9 l’efficacit\u00e9 du traitement au CO2 supercritique (2 heures) pour st\u00e9riliser des membranes nanoporeuses en hydrogel \u00e0 base de polyur\u00e9thane, destin\u00e9es \u00e0 l’encapsulation cellulaire en vue d’implants.\n

L’expertise d’AINIA en CO2 supercritique et encapsulation<\/strong><\/h3>\nAINIA poss\u00e8de plus de 25 ans d’exp\u00e9rience dans le d\u00e9veloppement et le transfert industriel de solutions bas\u00e9es sur les processus au CO2 supercritique<\/strong>, ainsi que plus de 15 ans d’exp\u00e9rience en encapsulation. En 2020, des progr\u00e8s ont \u00e9t\u00e9 r\u00e9alis\u00e9s dans le d\u00e9veloppement de proc\u00e9d\u00e9s d’encapsulation par CO2 supercritique, avec l’int\u00e9gration de nouveaux dispositifs exp\u00e9rimentaux.\n\nCes travaux ont \u00e9t\u00e9 cofinanc\u00e9s par l’IVACE (Institut Valencien de Comp\u00e9titivit\u00e9 des Entreprises) dans le cadre de son programme de soutien \u00e0 la recherche et au transfert technologique vers l’industrie.\n\n \n\n\"IVACE\"\n","protected":false},"excerpt":{"rendered":"

Le CO2 supercritique peut \u00eatre utilis\u00e9 non seulement pour obtenir des extraits adapt\u00e9s \u00e0 l’encapsulation, mais aussi \u00e0 d’autres \u00e9tapes du processus, telles que la g\u00e9n\u00e9ration de particules, l’impr\u00e9gnation de mat\u00e9riaux, la r\u00e9duction de la charge microbienne, et bien plus encore. Les pr\u00e9f\u00e9rences des consommateurs et les attentes de l’industrie incluent la recherche de produits […]<\/p>\n","protected":false},"author":345,"featured_media":70410,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[252],"tags":[],"tipo-documento":[],"class_list":["post-70409","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-non-classifiee"],"acf":[],"yoast_head":"\nProc\u00e9d\u00e9s au CO2 supercritique et encapsulation<\/title>\n<meta name=\"description\" content=\"Solutions d\u0092encapsulation innovantes et durables gr\u00e2ce au CO2 supercritique : extraction, particules et impr\u00e9gnation.\" \/>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" 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