{"id":72303,"date":"2023-03-01T00:00:00","date_gmt":"2023-03-01T00:00:00","guid":{"rendered":"https:\/\/ainia.endesarrollo.pro\/transparencia\/pharmanova\/"},"modified":"2023-03-01T00:00:00","modified_gmt":"2023-03-01T00:00:00","slug":"pharmanova","status":"publish","type":"transparencia","link":"https:\/\/ainia.endesarrollo.pro\/en\/transparencia\/pharmanova\/","title":{"rendered":"PHARMANOVA"},"content":{"rendered":"<p style=\"text-align: justify;\">\n<h2>Objective<\/h2>\n<p>The general objective of PHARMANOVA is to develop advanced technological tools and solutions for the search and development of targeted therapies based on natural biomolecules of plant and microbiological origin, enabling the design of innovative strategies to prevent and treat inflammatory processes associated with diseases of the colonic mucosa and colorectal cancer.<\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: justify;\">\n<h2>Activities<\/h2>\n<ol>\n<li>Development of screening platforms for potentially therapeutic use in mammalian cells<\/li>\n<li>Development of screening platforms for potentially therapeutic compounds of microbial origin.<\/li>\n<li>Research into supercritical CO2 fractionation strategies to obtain substances with potential for therapeutic applications.<\/li>\n<li>Study of encapsulation strategies for therapeutic molecules<\/li>\n<li>Development of advanced tissue tools for the study of new therapies<\/li>\n<li>Transfer of results<\/li>\n<li>Dissemination and communication<\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<h2>Results<\/h2>\n<ul>\n<li>Development of a s<strong>creening tool based on obtaining a genetically modified mammalian cell line<\/strong> equipped with a reporter system for a target or biomarker of inflammatory processes associated with the colonic mucosa.<\/li>\n<li>Development of a <strong>protocol for strain growth using miniaturised systems and systems<\/strong> for phenotypic screening of molecules.<\/li>\n<li>Development of an <strong>untargeted metabolomics method based on LC-HRMS\/MS<\/strong> that enables the relative identification and quantification of metabolites produced by various bacterial strains, providing a detailed understanding of the metabolic profiles of the strains studied.<\/li>\n<li><strong>Fractionation and encapsulation technologies for targeted therapies.<\/strong> Relevant advances in the <strong>development of fractionation processes using supercritical CO\u2082<\/strong>, aimed at obtaining<strong> fractions enriched in biomolecules with therapeutic potential from natural sources.<\/strong><\/li>\n<li><strong>Advanced coating and encapsulation system<\/strong> aimed at <strong>protecting and stabilising butyric acid.<\/strong><\/li>\n<li>Development of an advanced gastrointestinal system model. An <strong>advanced diagnostic cellular system has been developed<\/strong> that<strong> simulates colon inflammation<\/strong> using 3D<strong> organ-on-chip<\/strong> technology and combining cell types. <\/li>\n<li>Development of a<strong> label-free proteomics method<\/strong>, enabling the identification of differentially expressed proteins in response to treatment, based on LC-HRMS\/MS in combination with data processing using MaxQuant and Perseus.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p style=\"text-align: justify;\">\n<h2>Dissemination\/Transfer<\/h2>\n<ul>\n<li><a href=\"https:\/\/www.ainia.com\/wp-content\/uploads\/2021\/09\/03_-PHARMANOVA_R.pdf\">Project poster<\/a><\/li>\n<\/ul>\n<p>Press releases<\/p>\n<ul>\n<li><a href=\"https:\/\/www.ainia.com\/ainia-news\/ainia-desarrollara-13-nuevos-proyectos-de-id-financiados-por-ivace\/\" data-wpel-link=\"internal\">AINIA will develop 13 new R&#038;D projects funded by IVACE<\/a><\/li>\n<li><a href=\"https:\/\/www.ainia.com\/ainia-news\/estrategias-terapeuticas-innovadoras-contra-inflamacion-intestinal-cancer-colorrectal\/\">Innovative therapeutic strategies against intestinal inflammation and colorectal cancer<\/a><\/li>\n<li><a href=\"https:\/\/www.ainia.com\/ainia-news\/ainia-investiga-tecnologias-desarrollo-terapias-naturales-tratamiento-enfermedades-inflamatorias-colon\/\">AINIA researches innovative therapies to treat inflammatory colon diseases<\/a><\/li>\n<\/ul>\n<p>Dissemination articles<\/p>\n<ul>\n<li><a href=\"https:\/\/www.ainia.com\/ainia-news\/inflamacion-intestinal-cancer-colorrectal-terapias\/\">How can the complexity of intestinal inflammation and colorectal cancer be addressed more effectively?<\/a><\/li>\n<li><a href=\"https:\/\/www.ainia.com\/ainia-news\/organos-chip-potencial-alimentacion-cosmetica-farmacia\/\">Organs-on-chip and their potential in food, cosmetics and pharmaceuticals<\/a><\/li>\n<li><a href=\"https:\/\/www.ainia.com\/ainia-news\/conoce-los-ultimos-avances-y-tecnologias-relacionadas-con-los-cultivos-3d\/\">Discover the latest advances and technologies related to 3D cultures<\/a><\/li>\n<li><a href=\"https:\/\/www.ainia.com\/ainia-news\/innovacion-modelos-celulares-chip-organoides-enfermedades-farmacos\/\">Innovation in cellular models: Lab-on-a-Chip and organoids. For disease research and drug development <\/a><\/li>\n<li><a href=\"https:\/\/www.ainia.com\/ainia-news\/tecnologias-estrategias-terapeuticas-enfermedades-inflamatorias-intestino\/\">How can technologies help define targeted therapeutic strategies for inflammatory bowel diseases? <\/a><\/li>\n<\/ul>\n<p>Internal communication<\/p>\n<ul>\n<li><a href=\"https:\/\/agora.ainia.es\/hemos-presentado-13-propuestas-a-la-convocatoria-de-ayudas-ivace-feder-2023-y-una-a-la-dgi\/\" data-wpel-link=\"internal\">We have submitted 13 proposals to the IVACE-FEDER 2023 Aid call and one to the DGI<\/a><\/li>\n<li><a href=\"https:\/\/engage.cloud.microsoft\/main\/threads\/eyJfdHlwZSI6IlRocmVhZCIsImlkIjoiMzAwODY3NzUwNzIxOTQ1NyJ9?trk_copy_link=V1\">We share the videos and\/or articles on the results of 6 IVACE FEDER projects we are working on this year.<\/a><\/li>\n<\/ul>\n<p>Video<\/p>\n<ul>\n<li><a href=\"https:\/\/youtu.be\/KOAZOTisyZI\">PharmaNova: Research into innovative therapies to prevent and treat inflammatory processes<\/a><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><img decoding=\"async\" class=\"alignnone wp-image-154643\" src=\"https:\/\/ainia.endesarrollo.pro\/wp-content\/uploads\/logo-ivace-feder-2022.png\" alt=\"logo ivace feder 2022\" width=\"602\" height=\"63\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Advanced technological strategies for the search and development of targeted therapies from natural biomolecules<\/p>\n","protected":false},"featured_media":72304,"template":"","meta":{"_acf_changed":false,"footnotes":""},"transparencia_ainia_cat":[236],"transparencia_ainia_tag":[],"class_list":["post-72303","transparencia","type-transparencia","status-publish","has-post-thumbnail","hentry","transparencia_ainia_cat-subsidies-public-funding"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - 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